SH3 domain scaffold protein anti-Human Pyk2

Name: SH3 domain scaffold protein anti-Human Pyk2
SKU: SST-L190
Rating: 5 (1 reviews)

CAT#: SST-L190

The SH3 domain that bound Pyk2 was isolated from the library using Yeast Two-hybrid techonology. After affinity maturation, SH3 domain variants were identified having affinities for Pyk2 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3850/624_D4_2_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human cerebral cortex

Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in neuronal cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26091/ihc_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26091/58711_B_7_5.jpg

Normal Tissue Figure 4 Colon

Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26091/58711_A_8_3.jpg

Normal Tissue Figure 5 Liver

Cholangiocytes
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Nuclear
Hepatocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26091/58711_A_8_4.jpg

Normal Tissue Figure 6 Kidney

Cells in glomeruli
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26091/58711_A_8_5.jpg

Normal Tissue Figure 7 Testis

Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26091/58711_A_4_6.jpg

Normal Tissue Figure 8 Tonsil

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Squamous epithelial cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26091/58711_A_6_8.jpg

Normal Tissue Figure 9 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26091/58711_A_9_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enhanced (Daudi, REH)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000120899-PTK2B/subcellular

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Specifications

Scaffold Name
SH3 domain

Origin
PSD-95 protein

Target
Pyk2

Species Reactivity
Human

Expression Host
E. coli

Applications
ELISA; IHC; Microscopy; FC; WB; FuncS

Target

Alternative Names
PSD-95 protein; SH3 domain; CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK

Gene ID
2185

UniProt ID
Q14289

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Downloadable Resources

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Datasheet

Datasheet - SST-L190.pdf

MSDS

MSDS - SST-L190.pdf

COA

Certificate of Analysis Lookup

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