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Tositumomab (TP-108CL)

Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).      
Datasheet
Specifications
Classify
Protein therapeutics that deliver other compounds or proteins
Therapeutic
Tositumomab and 131I-tositumomab
Trade Name
Bexxar, Bexxar I-131
Function
Tositumomab is a mAb that binds CD20 surface antigen and stimulates apoptosis. Tositumomab coupled to radioactive iodine-131 binds CD20 surface antigen and delivers cytotoxic radiation
Examples of Clinical Use
CD20+ follicular NHL, with and without transformation, in patients whose disease is refractory to rituximab and has relapsed following chemotherapy; tositumomab and then 131I-tositumomab are used sequentially in the treatment regimen
References
Synonyms
Ig gamma-1 chain C region
UniProt
P01857
Genbank
J00228

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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