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Z-domain of protein A anti-FCGRT (SZA-L218)

This ectodomain of human FcRn specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities for ectodomain of human FcRn as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      
Datasheet
Specifications
Scaffold Name
Z-domain of protein A
Origin
Staphylococcal protein A
Core Structure
3-α helixes
Variable Regions
13 Residues on first and second helix surface
Target
Ectodomain of human FcRn
Species Reactivity
Human
Expression Host
E. coli
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
Staphylococcal protein A; Z-domain of protein A; FCRN; alpha-chain
Entrez Gene ID
2217
UniProt ID
P55899

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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