Human Anti-FCGRT scFv-Fc Chimera (VS-0325-FY184)

CAT#: VS-0325-FY184

The anti-FcRn scFv-Fc antibody targets the neonatal Fc receptor (FcRn), which plays a crucial role in IgG homeostasis and immune response. This antibody is designed to provide specific targeting of FcRn, with potential applications in research related to IgG metabolism, immune tolerance, and the development of therapeutic strategies targeting FcRn-mediated pathways.

Gene Expression
Figure 1 RNA cell line category: Cell line enhanced (ASC diff, Hep G2, OE19, THP-1)

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • Human FCGRT
  • Species Reactivity
  • Human
  • Applications
  • ELISA
  • Related Disease
  • Autoimmune Disease

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Target

  • Alternative Names
  • Fc Fragment Of IgG Receptor And Transporter; Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor; Transmembrane Alpha Chain Of The Neonatal Receptor; Fc Fragment Of IgG, Receptor, Transporter, Alpha; IgG Fc Fragment Receptor Transporter Alpha Chain; Neonatal Fc Receptor; FCRN
  • Long Name
  • Fc Fragment Of IgG Receptor And Transporter
  • Sequence Similarities
  • Belongs to the immunoglobulin superfamily.
  • Cellular Localization
  • Cell membrane; Endosome membrane
  • Post Translation Modifications
  • Glycosylation at Asn125
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyConnect FCGRN_HUMAN (1387)
    Glycosylation from GlyGen 2 sites, 48 N-linked glycans (1 site), 1 O-linked glycan (1 site)
  • Function
  • Human FCGRT (Fc receptor, IgG, neonatal) is an Fc receptor that plays a crucial role in IgG antibody recycling and transport. It influences antibody half-life and is a target for therapeutic modulation of IgG levels.
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

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COA

Certificate of Analysis Lookup

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Isotype Control

Secondary Antibody

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