Human Anti-FCGRT scFv-Fc Chimera (VS-0325-FY184) (CAT#: VS-0325-FY184)
The anti-FcRn scFv-Fc antibody targets the neonatal Fc receptor (FcRn), which plays a crucial role in IgG homeostasis and immune response. This antibody is designed to provide specific targeting of FcRn, with potential applications in research related to IgG metabolism, immune tolerance, and the development of therapeutic strategies targeting FcRn-mediated pathways.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (ASC diff, Hep G2, OE19, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104870-FCGRT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104870-FCGRT
Figure 1 RNA cell line category: Cell line enhanced (ASC diff, Hep G2, OE19, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104870-FCGRT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104870-FCGRT
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human FCGRT
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Autoimmune Disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Fc Fragment Of IgG Receptor And Transporter; Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor; Transmembrane Alpha Chain Of The Neonatal Receptor; Fc Fragment Of IgG, Receptor, Transporter, Alpha; IgG Fc Fragment Receptor Transporter Alpha Chain; Neonatal Fc Receptor; FCRN
- Gene ID
- 2217
- UniProt ID
- P55899
- Long Name
- Fc Fragment Of IgG Receptor And Transporter
- Sequence Similarities
- Belongs to the immunoglobulin superfamily.
- Cellular Localization
- Cell membrane; Endosome membrane
- Post Translation Modifications
- Glycosylation at Asn125
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect FCGRN_HUMAN (1387)
Glycosylation from GlyGen 2 sites, 48 N-linked glycans (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047294364.1; XP_047294366.1; XP_047294367.1; XP_047294368.1; XP_054176174.1
- Function
- Human FCGRT (Fc receptor, IgG, neonatal) is an Fc receptor that plays a crucial role in IgG antibody recycling and transport. It influences antibody half-life and is a target for therapeutic modulation of IgG levels.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ADCC Enhanced Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0418ZL | Mouse Anti-FCGRT Recombinant Antibody (clone YC053) | FC, ELISA | |
| HPAB-0720LY | Mouse Anti-FCGRT Recombinant Antibody (HPAB-0720LY) | ELISA, FuncS | Mouse IgG |
| HPAB-0721LY | Mouse Anti-FCGRT Recombinant Antibody (HPAB-0721LY) | ELISA, FuncS | Mouse IgG |
| HPAB-0722LY | Mouse Anti-FCGRT Recombinant Antibody (HPAB-0722LY) | ELISA, FuncS | Mouse IgG |
| HPAB-0723LY | Mouse Anti-FCGRT Recombinant Antibody (HPAB-0723LY) | ELISA, FuncS | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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