FITC-A*24:02/Human BCL2A1 (DYLQYVLQI) MHC Tetramer (CAT#: MHC-CN0423)

• Allele
• A*24:02

• Class
• Class I

• MHC Species
• Human

• Antigen
• BCL2A1

• Antigen Species
• Human

• Peptide
• DYLQYVLQI

• Conjugate
• FITC

• Application
• FCM, IHC

• Antigen Introduction
• This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Alternative Names
• BCL2 Related Protein A1; Hemopoietic-Specific Early Response Protein; Bcl-2-Like Protein 5; Protein BFL-1; Bcl2-L-5; BCL2L5; HBPA1; BFL1; GRS;

• Gene ID
• 597

• UniProt ID
• Q16548

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