Rabbit Anti-ADRA1A Recombinant Antibody (VS13-YC28) (CAT#: VS13-YC28)
The Rabbit Anti-ADRA1A Recombinant Antibody is specific for human and rat ADRA1A. ADRA1A encodes the alpha-1A-adrenergic receptor, a G protein-coupled receptor subtype, which regulates cell growth and proliferation, exhibiting four transcript variants from alternative splicing. The anti-ADRA1A antibody can be used for Western blot (1/500-1/1000), Immunohistochemistry (1/50-1/100).
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Subcellular Location
Normal Tissue
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76693/1958_G3_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76693/1958_G3_2_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in astrocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/ihc_selected.jpg
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in astrocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/ihc_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/70377_B_7_5.jpg
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/70377_B_7_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/70377_A_4_6.jpg
(Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/70377_A_4_6.jpg
Specifications
- Immunogen
- Recombinant human alpha 1a adrenergic receptor.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat ADRA1A
- Species Reactivity
- Human, Rat
- Applications
- WB, IHC-P
- Conjugate
- NONE
- Related Disease
- Ureterolithiasis and Central Nervous System Origin Vertigo
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Target
- Alternative Names
- Adrenoceptor Alpha 1A; Adrenergic, Alpha-1A-, Receptor; Alpha-1C Adrenergic Receptor; Alpha-1A Adrenoreceptor; Alpha-1A Adrenoceptor; ADRA1C;
- Gene ID
- 148
- UniProt ID
- P35348
- Long Name
- Adrenoceptor Alpha 1A
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
- Cellular Localization
- Cell membrane; Cytoplasm; Membrane; Nucleus
- Protein Refseq
- NP_000671.2; NP_001309431.1; NP_001309432.1; NP_001309433.1; NP_150645.2
- Function
- This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G11 proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0090 | Hi-Affi™ Rabbit Anti-ADRA1A Recombinant Antibody (clone DS90AB) | WB, ICC, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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