Anti-AIM2 (clone W24V55) Recombinant Antibody Coupled Liposome (VS-1024-FY59)
CAT#: VS-1024-FY59
Anti-AIM2 antibody-conjugated liposomes have shown potential in inhibiting tumor growth in breast cancer research. Studies indicate that AIM2 expression can inhibit the proliferation of human breast cancer cells and reduce breast tumor growth in mouse models. This AIM2-based therapeutic approach offers new ideas for the treatment of breast cancer.
AIM2 is a key sensor in the immune response, and its targeting via antibody-conjugated liposomes offers a novel approach to enhance tumor immunotherapy in melanoma. This strategy aims to selectively deliver therapeutic agents to melanoma cells, potentially increasing treatment efficacy. The liposomes improve the stability and bioavailability of the antibody, facilitating a targeted attack on tumor cells. Preclinical studies suggest enhanced antitumor activity and a more favorable safety profile.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40309/1396_B8_4_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_7_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_4_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70, U-266/84, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163568-AIM2
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer, Melanoma
Product Composition
- Clone
- W24V55
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant antibody derived from mouse sources, specifically designed to recognize and bind to the AIM2 protein. AIM2, or absent in melanoma 2, is an important component of the immune response, known for its role in detecting cytosolic DNA and activating the innate immune pathway.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- AIM2
- Introduction
- AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
- Alternative Names
- Absent In Melanoma 2; Interferon-Inducible Protein AIM2; PYHIN4
- Full Name
- Absent In Melanoma 2
- Gene ID
- 911829
- UniProt ID
- Q05320
- Sequence Similarities
- Belongs to the HIN-200 family.
- Cellular Localization
- Cytoplasm; Inflammasome; Nucleus
- Post Translation Modifications
- Degraded via selective autophagy following interaction with TRIM11. ( O14862-AIM2_HUMAN )
Modification sites at PhosphoSitePlus ( O14862 )
Modification sites at neXtProt
- Protein Refseq
- XP_047290764.1; XP_047290765.1; XP_047290767.1; XP_054195659.1; XP_054195660.1
- Function
- Acts as a recognition receptor (PRR): specifically recognizes and binds dsDNA in the cytosol, and mediates the formation of the inflammasome polymeric complex composed of AIM2, CASP1 and PYCARD/ASC.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC191 | PE-A*01:01/Human AIM2 (RSDSGQQARY) MHC Tetramer | FCM | |
| MHC-LC192 | APC-A*01:01/Human AIM2 (RSDSGQQARY) MHC Tetramer | FCM | |
| MHC-YF316 | A*01:01/Human AIM-2 (RSDSGQQARY) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX26 | Mouse Anti-AIM2 Recombinant Antibody (clone 4G-11) | WB, ICC, FC | Mouse IgG1 |
| VS3-XY33 | Mouse Anti-AIM2 Recombinant Antibody (clone 3F12F3) | ELISA, WB, ICC, FC | Mouse IgG1 |
| VS3-XY34 | Mouse Anti-AIM2 Recombinant Antibody (clone 2G1D5) | ELISA, WB, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY69 | Anti-AIM2 Immunohistochemistry Kit | IHC |
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