Anti-APLNR Antibody Prodrug, Protease Activated (VS-1025-YC117)
CAT#: VS-1025-YC117
The Anti-APLNR Antibody Prodrug, Protease Activated (VS-1025-YC117) is an antibody prodrug comprised of a recombinant mouse antibody targeting human APLNR, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to APLNR protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to APLNR effectively. APLNR (Apelin Receptor) is a G protein-coupled receptor whose signaling is increasingly recognized for promoting tumor angiogenesis and metastasis. Its activation by the ligand apelin drives the formation of new blood vessels and is associated with malignant progression in several solid tumors.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25842/57343_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (AF22, HEL, K-562, NTERA-2, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134817-APLNR
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human APLNR
- Target
- APLNR
- Species Reactivity
- Human
- Isotype
- IgG1
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "APLNR"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0929CLV | Mouse Anti-APLNR Recombinant Antibody (TAB-0929CLV) | ELISA | Mouse IgG1 |
| TAB-0930CLV | Human Anti-APLNR Recombinant Antibody (TAB-0930CLV) | ELISA | Chimeric (mouse/human) IgG |
| TAB-0931CLV | Human Anti-APLNR Recombinant Antibody (TAB-0931CLV) | ELISA | Chimeric (mouse/human) IgG |
| TAB-0929CLV-F(E) | Mouse Anti-APLNR Recombinant Antibody (TAB-0929CLV-F(E)); Fab Fragment | ELISA | Mouse Fab |
| TAB-0930CLV-F(E) | Human Anti-APLNR Recombinant Antibody; Fab Fragment (TAB-0930CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0932CLV | Human Anti-APLNR Recombinant Antibody (TAB-0932CLV) | ELISA | Human IgG4 |
| TAB-0933CLV | Human Anti-APLNR Recombinant Antibody (TAB-0933CLV) | ELISA | Human IgG4 |
| TAB-0934CLV | Human Anti-APLNR Recombinant Antibody (TAB-0934CLV) | ELISA | Human IgG4 |
| TAB-0935CLV | Human Anti-APLNR Recombinant Antibody (TAB-0935CLV) | ELISA | Human IgG4 |
| TAB-0936CLV | Human Anti-APLNR Recombinant Antibody (TAB-0936CLV) | ELISA | Human IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0007 | Camelid Anti-APLNR Recombinant Antibody (PABJ-0007) | ELISA, Antagonist | Camelid VHH |
| PABJ-0008 | Camelid Anti-APLNR Recombinant Antibody (PABJ-0008) | ELISA, Agonist | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC642 | AbPlus™ Anti-APLNR Magnetic Beads (VS-0724-YC642) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC419 | Recombinant Anti-APLNR Vesicular Antibody, EV Displayed (VS-0425-YC419) | Antagonist, ELISA, FC, Cell-uptake |
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