Mouse Anti-ARRB1 Recombinant Antibody (clone Fab30) (CAT#: VS-0524-YC4)
Fab30 selectively recognizes and stabilizes an active βarr1 conformation induced by the binding of a phosphorylated peptide corresponding to the carboxyl terminus of the human vasopressin receptor (V2R). Fab30 also exhibited similar potentiation of βarr1-pERK2 (active ERK2) interaction.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49318/if_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49318/if_selected.jpg
Figure 2 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic and nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_B_9_5_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic and nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_B_9_5_selected.jpg
Figure 3 IHC staining of human cerebellum
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3763/ihc_selected.jpg
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3763/ihc_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_B_9_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_B_9_5.jpg
Figure 5 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_7_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_7_3.jpg
Figure 6 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_9_4.jpg
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_9_4.jpg
Figure 7 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_9_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_9_5.jpg
Figure 8 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_6_6.jpg
Figure 9 RNA cell line category: Cell line enhanced (HEL, RH-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137486-ARRB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137486-ARRB1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human Arrestin, beta 1
- Species Reactivity
- Human
- Clone
- Fab30
- Applications
- ELISA, IP, FuncS
- Related Disease
- Placenta Praevia and Nephrogenic Syndrome Of Inappropriate Antidiuresis.
Product Property
- Purification
- Protein G purified
- Purity
- >95%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservative
- Storage
- Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Arrestin Beta 1; Non-Visual Arrestin-2; Arrestin 2; ARR1; Arrestin, Beta 1; Beta-Arrestin-1; Arrestin Beta-1; ARB1;
- Gene ID
- 408
- UniProt ID
- P49407
- Long Name
- Arrestin, beta 1
- Sequence Similarities
- Belongs to the arrestin family.
- Cellular Localization
- Cytoplasm
Nucleus
Cell membrane
Membrane, clathrin-coated pit {ECO:0000305}
Cell projection, pseudopodium {ECO:0000250}
Cytoplasmic vesicle
- Post Translation Modifications
- Constitutively phosphorylated at Ser-412 in the cytoplasm.
Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2.
Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex.
Modification sites at neXtProt (NX_P49407)
Glycosylation from GlyGen (P49407) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011543336.1; XP_011543337.1; XP_016873239.1; XP_016873240.1; XP_016873241.1
- Function
- Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-689 | Mouse Anti-ARRB1 Recombinant Antibody (clone mAb 30) | ELISA | Mouse IgG |
| MRO-1691-CN | Rabbit Anti-ARRB1 Polyclonal Antibody (MRO-1691-CN) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0519F | Mouse Anti-ARRB1 Recombinant Antibody (ZG-0519F) | WB | Mouse IgG |
| ZG-0520F | Mouse Anti-ARRB1 Recombinant Antibody (ZG-0520F) | WB | Mouse IgG |
| VS3-WK2021 | Rabbit Anti-ARRB1 (pS412) Recombinant Antibody (clone R05-6F7) | WB, IHC-P, IP | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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