Mouse Anti-ARRB1 Recombinant Antibody (clone Fab30)
CAT#: VS-0524-YC4
Fab30 selectively recognizes and stabilizes an active βarr1 conformation induced by the binding of a phosphorylated peptide corresponding to the carboxyl terminus of the human vasopressin receptor (V2R). Fab30 also exhibited similar potentiation of βarr1-pERK2 (active ERK2) interaction.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49318/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic and nuclear positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_B_9_5_selected.jpg
Normal Tissue
Figure 3 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3763/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_7_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70249/164031_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HEL, RH-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137486-ARRB1
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human Arrestin, beta 1
- Species Reactivity
- Human
- Clone
- Fab30
- Applications
- ELISA, IP, FuncS
- Related Disease
- Placenta Praevia and Nephrogenic Syndrome Of Inappropriate Antidiuresis.
Product Property
- Purification
- Protein G purified
- Purity
- >95%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservative
- Storage
- Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Arrestin Beta 1; Non-Visual Arrestin-2; Arrestin 2; ARR1; Arrestin, Beta 1; Beta-Arrestin-1; Arrestin Beta-1; ARB1;
- Gene ID
- 408
- UniProt ID
- P49407
- Long Name
- Arrestin, beta 1
- Sequence Similarities
- Belongs to the arrestin family.
- Cellular Localization
- Cytoplasm
Nucleus
Cell membrane
Membrane, clathrin-coated pit {ECO:0000305}
Cell projection, pseudopodium {ECO:0000250}
Cytoplasmic vesicle
- Post Translation Modifications
- Constitutively phosphorylated at Ser-412 in the cytoplasm.
Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2.
Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex.
Modification sites at neXtProt (NX_P49407)
Glycosylation from GlyGen (P49407) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011543336.1; XP_011543337.1; XP_016873239.1; XP_016873240.1; XP_016873241.1
- Function
- Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
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- Product Name
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- CAT
- Product Name
See other products for "Arrb1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-689 | Mouse Anti-ARRB1 Recombinant Antibody (clone mAb 30) | ELISA | Mouse IgG |
| MRO-1691-CN | Rabbit Anti-ARRB1 Polyclonal Antibody (MRO-1691-CN) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0519F | Mouse Anti-ARRB1 Recombinant Antibody (ZG-0519F) | WB | Mouse IgG |
| ZG-0520F | Mouse Anti-ARRB1 Recombinant Antibody (ZG-0520F) | WB | Mouse IgG |
| VS7-HM138 | Mouse Anti-ARRB1 Recombinant Antibody (clone CBL053HM) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-682 | Mouse Anti-ARRB1 Recombinant Antibody (clone 30); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-682 | Mouse Anti-ARRB1 Recombinant Antibody (clone 30); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0260 | Hi-Affi™ Rabbit Anti-ARRB1 Recombinant Antibody (clone DS260AB) | WB, FC, IHC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY181 | Anti-ARRB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY536 | Anti-Human ARRB1 Immunohistochemistry Kit | IHC |
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