Mouse Anti-ARRB1 Recombinant Antibody (clone Fab30) (CAT#: VS-0524-YC4)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human Arrestin, beta 1

• Species Reactivity
• Human

• Clone
• Fab30

• Applications
• ELISA, IP, FuncS

• Related Disease
• Placenta Praevia and Nephrogenic Syndrome Of Inappropriate Antidiuresis.

• Purification
• Protein G purified

• Purity
• >95%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservative

• Storage
• Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• Arrestin Beta 1; Non-Visual Arrestin-2; Arrestin 2; ARR1; Arrestin, Beta 1; Beta-Arrestin-1; Arrestin Beta-1; ARB1;

• Gene ID
• 408

• UniProt ID
• P49407

• Long Name
• Arrestin, beta 1

• Sequence Similarities
• Belongs to the arrestin family.

• Cellular Localization
• Cytoplasm
  Nucleus
  Cell membrane
  Membrane, clathrin-coated pit {ECO:0000305}
  Cell projection, pseudopodium {ECO:0000250}
  Cytoplasmic vesicle

• Post Translation Modifications
• Constitutively phosphorylated at Ser-412 in the cytoplasm.
  Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2.
  Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex.
  Modification sites at neXtProt (NX_P49407)
  Glycosylation from GlyGen (P49407) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_011543336.1; XP_011543337.1; XP_016873239.1; XP_016873240.1; XP_016873241.1

• Function
• Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes.

Secondary Antibody

• 2ND-042CQ
• Rabbit Anti-Mouse IgG (H&L) Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

• MOB-203CQ
• Mouse IgG2b, kappa Isotype Control Antibody

• MOB-202CQ
• Mouse IgG2a, kappa Isotype Control Antibody

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