Rabbit Anti-ATG16L1 Recombinant Antibody (clone R05-8U2) (CAT#: VS3-XY3269)

Name: Rabbit Anti-ATG16L1 Recombinant Antibody (clone R05-8U2)
SKU: VS3-XY3269
Rating: 5 (1 reviews)

This is a recombinant rabbit antibody that specifically recognizes human ATG16L1 (Autophagy related 16 like 1), which plays an essential role in both canonical and non-canonical autophagy. It also has cross-reactivity against mouse or rat ATG16L1. It has been reported for use in Western Blot and Immunohistochemistry-Paraffin. The recommended dilutions of Western Blot and Immunohistochemistry-Paraffin is 1/500-1/1000 and 1/50-1/100.

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Gene Expression
Datasheet
MSDS
COA

Subcellular Location

Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12577/if_selected.jpg

Normal Tissue

Figure 2 IHC staining of human gallbladder
(Immunohistochemical staining of human gallbladder shows membrane positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63900/151700_A_4_4_selected.jpg

Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63900/151700_B_9_5.jpg

Figure 4 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63900/151700_A_9_3.jpg

Figure 5 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63900/151700_A_9_4.jpg

Figure 6 Kidney
(Distal tubules Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63900/151700_A_8_5.jpg

Figure 7 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Round or early spermatids Staining: High Intensity: Strong Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63900/151700_A_4_6.jpg

RNA Expression

Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000085978-ATG16L1

Datasheet

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Human, Mouse and Rat ATG16L1

Species Reactivity
Human, Mouse, Rat

Clone
R05-8U2

Applications
WB, IHC-P

Related Disease
Inflammatory Bowel Disease 10; Inflammatory Bowel Disease

Product Property

Clonality
Monoclonal

Aggregation
< 5%

Format
Liquid

Buffer
PBS (pH 7.4), 150 mM NaCl and 50% glycerol

Preservative
0.02% sodium azide

Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
WB: 1/500-1/1000
IHC: 1/50-1/100

Target

Alternative Names
IBD10; WDR30; APG16L; ATG16A; ATG16L

Gene ID
55054

UniProt ID
Q676U5

Long Name
Autophagy related 16 like 1

Cellular Localization
Cytoplasm, Endosome, Lysosome, Membrane

Post Translation Modifications
Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.

Protein Refseq
XP_005246143.1; XP_005246141.1

Function
Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins.
Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling.
Plays a role in regulating morphology and function of Paneth cell.

Isotype Control

Recommended Dilution Buffer

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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IgG Antibody Products Rabbit Monoclonal Antibody Products

CAT	Product Name	Application	Type
MOB-3228z	Mouse Anti-ATG16L1 Recombinant Antibody (clone 41G9)	WB, IP, IF, ELISA	Mouse IgG1, κ
MRO-0136-CN	Rabbit Anti-ATG16L1 Recombinant Antibody (clone JU30-62)	WB	Rabbit IgG
VS3-QX71	Mouse Anti-ATG16L1 Recombinant Antibody (clone 54CT27.2.6)	WB, IHC	Mouse IgG1
VS3-WK805	Rabbit Anti-ATG16L1 Recombinant Antibody (clone VS3-WK805)	WB, ELISA	Rabbit IgG
VS3-FY107	Recombinant Rabbit Anti-ATG16L1 Antibody (clone R03-4G8)	WB	Rabbit IgG

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