AbPlus™ Anti-ATM Magnetic Beads (4E11) (CAT#: VS-0424-XY24)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magrose bead (> 50 μmol/mL gel)

• Bead Ligand
• Anti-ATM specific antibody (4E11)

• Target
• ATM

• Immunogen
• Synthesized peptide derived from human ATM

• Target Species
• Human

• Antibody Clone
• 4E11

• Bead Capacity
• 20-30 mg/mL binding antibody

• Bead size
• 10-37 μm

• Stability
• pH 2-14

• Format
• 20% Suspension

• Buffer
• PBS, pH 7.4, with 1% BSA

• Preservative
• 0.03% Proclin 300

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

• Alternative Names
• AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; serine-protein kinase ATM; A-T mutated; AT mutated; TEL1, telomere maintenance 1, homolog; ataxia telangiectasia mutated

• Gene ID
• 472

• UniProt ID
• Q13315

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