Rabbit Anti-BANF1 Recombinant Antibody (VS13-YC87)
CAT#: VS13-YC87
The Rabbit Anti-BANF1 Recombinant Antibody is specific for human BANF1. BANF1 encodes a protein that protects against retroviral integration, associated with chromosomes during mitosis, binding DNA and nuclear envelope proteins, with spliced variants encoding the same protein. The anti-BANF1 antibody can be used for Western blot (1/500-1/1000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39242/if_selected.jpg
Normal Tissue
Figure 2 Skeletal muscle
High expression in skeletal muscle
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39242/135600_B_3_6_val_selected.jpg
Normal Tissue
Figure 3 IHC staining of human esophagus
Immunohistochemical staining of human esophagus shows nuclear membranous positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32896/158720_B_4_1_selected.jpg
Normal Tissue
Figure 4 Heart muscle
Cardiomyocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39242/135600_B_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000175334-BANF1
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Specifications
- Immunogen
- Recombinant human BANF1, aa 6-19.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human BANF1
- Species Reactivity
- Human
- Applications
- WB
- Conjugate
- NONE
- Related Disease
- Nestor-Guillermo Progeria Syndrome and Vaccinia
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Target
- Alternative Names
- Barrier To Autointegration Factor 1; Breakpoint Cluster Region Protein 1; BAF; Barrier-To-Autointegration Factor; D14S1460; BCRP1; BCRG1; NGPS;
- Gene ID
- 8815
- UniProt ID
- O75531
- Long Name
- Barrier To Autointegration Factor 1
- Sequence Similarities
- Belongs to the BAF family.
- Cellular Localization
- Chromosome; Cytoplasm; Nucleus
- Protein Refseq
- NP_001137457.1; NP_003851.1
- Function
- Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA.
Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging.
Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner.
Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface.
Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity.
Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "BANF1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0463MZ | Mouse Anti-BANF1 Recombinant Antibody (clone CBLS-035) | IF, IHC-P, WB | Mouse IgG2a |
| MRO-0153-CN | Rabbit Anti-BANF1 Recombinant Antibody (clone JG40-43) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-FY1621 | Rabbit Anti-BANF1 Recombinant Antibody (clone R09-3F2) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0325 | Hi-Affi™ Rabbit Anti-BANF1 Recombinant Antibody (clone DS325AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY693 | Anti-BANF1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY694 | Anti-Mouse BANF1 Immunohistochemistry Kit | IHC |
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