Rabbit Anti-BANF1 Recombinant Antibody (VS13-YC87) (CAT#: VS13-YC87)

• Immunogen
• Recombinant human BANF1, aa 6-19.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human BANF1

• Species Reactivity
• Human

• Applications
• WB

• Conjugate
• NONE

• Related Disease
• Nestor-Guillermo Progeria Syndrome and Vaccinia

• Clonality
• Monoclonal

• Purification
• Affinity Chromatography purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.

• Preservative
• 0.01% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500-1/1000

• Alternative Names
• Barrier To Autointegration Factor 1; Breakpoint Cluster Region Protein 1; BAF; Barrier-To-Autointegration Factor; D14S1460; BCRP1; BCRG1; NGPS;

• Gene ID
• 8815

• UniProt ID
• O75531

• Long Name
• Barrier To Autointegration Factor 1

• Sequence Similarities
• Belongs to the BAF family.

• Cellular Localization
• Chromosome; Cytoplasm; Nucleus

• Protein Refseq
• NP_001137457.1; NP_003851.1

• Function
• Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA.
  Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging.
  Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner.
  Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface.
  Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity.
  Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Select a product category from the dropdown menu below to view related products.