Anti-BRCA1 (clone W24V216) Recombinant Antibody Coupled Liposome (VS-1024-FY213)
CAT#: VS-1024-FY213
Anti-BRCA1 antibody-conjugated liposomes show great potential in ovarian cancer research. Firstly, they can specifically target BRCA1-expressing cells, enhancing drug targeting and reducing systemic side effects. Secondly, this liposome carrier can effectively deliver anticancer drugs or gene therapy molecules, thereby improving therapeutic efficacy. Finally, by combining with BRCA1-targeting antibodies, these liposomes are expected to overcome drug resistance and enhance the treatment response rate in ovarian cancer patients.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & nuclear bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4840/1914_E5_15_cr5c8770e98e94d_selected.jpg
Normal Tissue
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong nuclear positivity in a subset of cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34966/89241_A_4_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_A_9_3.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_A_6_6.jpg
Normal Tissue
Figure 6 Skin
Epidermal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_B_5_8.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1946/5290_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000012048-BRCA1
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More Infomation
Specifications
- Potential Clinical Applications
- Ovarian cancer
Product Composition
- Clone
- W24V216
- Antibody Type
- IgG1
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This recombinant mouse monoclonal antibody has been meticulously developed to interact with the BRCA1 protein. BRCA1 is vital for DNA repair and maintaining genomic stability; mutations in this gene are commonly associated with increased risks of breast and ovarian cancers. The antibody's ability to recognize and bind to BRCA1 may facilitate advancements in understanding cancer biology and developing targeted therapies for patients with BRCA1-related tumors.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- BRCA1
- Introduction
- This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
- Alternative Names
- IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53
- Full Name
- BRCA1, DNA Repair Associated
- Gene ID
- 672
- UniProt ID
- P38398
- Cellular Localization
- Nucleus, Chromosome, Cytoplasm
- Post Translation Modifications
- Glycosylation at Asn247 ( NX_P38398 [NX_P38398-1] )
Ubiquitination at Lys987 ( NX_P38398 [NX_P38398-1] )
Modification sites at PhosphoSitePlus ( P38398 )
Glycosylation from GlyConnect BRCA1_HUMAN (2024)
Glycosylation from GlyGen (P38398) 3 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001394500.1; NP_001394510.1; NP_001394511.1; NP_001394512.1; NP_001394514.1
- Function
- E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, 12887909, 12890688, 14976165, 16818604, 17525340, 19261748).
It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688).
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, 14976165, 20351172).
Regulates centrosomal microtubule nucleation.
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Datasheet
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COA
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See other products for "BRCA1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-123 | Recombinant Anti-human BRCA1 Antibody | ELISA, WB, Neut, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-123-F(E) | Recombinant Anti-human BRCA1 Antibody Fab Fragment | FC, Neut, Funcs | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-123-S(P) | Recombinant Anti-human BRCA1 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-123 | Recombinant Human Anti-human BRCA1 Antibody | FC, ELISA, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-123-F(E) | Recombinant Human Anti-human BRCA1 Antibody Fab Fragment | WB, Dot, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-123-S(P) | Recombinant Human Anti-human BRCA1 Antibody scFv Fragment | WB, IHC, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1473MZ | Mouse Anti-BRCA1 Recombinant Antibody (clone 7C5) | IP, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0071MZ | Chicken Anti-BRCA1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY137 | Mouse Anti-BRCA1 Recombinant Antibody (clone 6C6D2) | ELISA, WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1325 | Mouse Anti-BRCA1 Recombinant Antibody (VS3-WK1325) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY824 | Anti-BRCA1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY825 | Anti-Mouse BRCA1 Immunohistochemistry Kit | IHC |
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