Anti-BTLA Antibody Prodrug, Protease Activated (VS-1025-YC175)
CAT#: VS-1025-YC175
The Anti-BTLA Antibody Prodrug, Protease Activated (VS-1025-YC175) is an antibody prodrug comprised of a recombinant human antibody targeting human BTLA, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to BTLA protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to BTLA effectively. BTLA (B- and T-Lymphocyte Attenuator) is an inhibitory immune checkpoint receptor on T-cells that contributes to T-cell exhaustion and immune evasion in the tumor microenvironment. Its activation by its ligand, HVEM, suppresses the anti-tumor immune response.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human spleen
Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in a subset of cells in red pulp.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47211/ihc_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62029/ihc_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62029/148776_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186265-BTLA
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human BTLA
- Target
- BTLA
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants.
- Alternative Names
- B- And T-Lymphocyte Attenuator; CD272 Antigen; BTLA1; CD272
- Gene ID
- 151888
- UniProt ID
- Q7Z6A9
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
| TAB-1309CL | Human Anti-BTLA Recombinant Antibody (TAB-1309CL) | Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1310CL | Human Anti-BTLA Recombinant Antibody (TAB-1310CL) | Block | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1311CL | Human Anti-BTLA Recombinant Antibody (TAB-1311CL) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1309CL-S(P) | Human Anti-BTLA Recombinant Antibody; scFv Fragment (TAB-1309CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1310CL-S(P) | Human Anti-BTLA Recombinant Antibody; scFv Fragment (TAB-1310CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2352MZ | Recombinant Mouse Anti-Human BTLA Antibody | WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-074CQ | Mouse Anti-BTLA Recombinant Antibody (clone PJ196) | Block, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-075CQ | Hamster Anti-BTLA Recombinant Antibody (clone 6A6) | FC, IP, Block | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-076CQ | Mouse Anti-BTLA Recombinant Antibody (clone 6F7) | FC, FuncS, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1605LY-S(P) | Human Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-1605LY-S(P)) | ELISA, FC | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1605LY | Human Anti-BTLA Recombinant Antibody (HPAB-1605LY) | ELISA, FC | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1605LY-F(E) | Human Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-1605LY-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0448-YC | Mouse Anti-BTLA Recombinant Antibody (HPAB-M0448-YC) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0448-YC-S(P) | Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-M0448-YC-S(P)) | FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0448-YC-F(E) | Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-M0448-YC-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-025CQ | Rat Anti-BTLA Recombinant Antibody (FN-025CQ) | FC, ELISA, FuncS | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-035CQ | Mouse Anti-BTLA Recombinant Antibody (clone ANC6E9) | ELISA, FC, FuncS | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0194-WJ-S(P) | Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-0194-WJ-S(P)) | ELISA, FC, WB, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0195-WJ-S(P) | Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-0195-WJ-S(P)) | ELISA, FC, WB, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0196-WJ-S(P) | Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-0196-WJ-S(P)) | ELISA, FC, WB, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0194-WJ-F(E) | Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-0194-WJ-F(E)) | ELISA, FC, WB, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0195-WJ-F(E) | Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-0195-WJ-F(E)) | ELISA, FC, WB, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0196-WJ-F(E) | Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-0196-WJ-F(E)) | ELISA, FC, WB, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY6 | CytoStream™ Mouse Anti-BTLA Recombinant Antibody (VS-0225-XY6) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY62 | Human Anti-BTLA (clone icatolimab) scFv-Fc Chimera | ELISA, FC | Human IgG4, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC609 | Recombinant Anti-BTLA Vesicular Antibody, EV Displayed (VS-0425-YC609) | ELISA, FC, SPR, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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