Human Anti-BTLA (clone icatolimab) scFv-Fc Chimera
CAT#: VS-0325-FY62
Anti-BTLA scFv-Fc antibody is a genetically engineered fusion protein that combines a single-chain variable fragment (scFv) of an antibody specific to B and T Lymphocyte Attenuator (BTLA) with the Fc region of an immunoglobulin (IgG). This design allows the antibody to maintain specificity for BTLA while gaining the functional properties associated with the Fc domain, such as increased stability and enhanced effector functions.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human spleen
Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in a subset of cells in red pulp.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47211/ihc_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62029/ihc_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62029/148776_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186265-BTLA
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Specifications
- Immunogen
- Recombinant human BTLA protein.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human BTLA
- Species Reactivity
- Human
- Clone
- icatolimab
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 1:5000-10000
Flow Cytometry: 1:100
Target
- Alternative Names
- B And T Lymphocyte Associated; B- And T-Lymphocyte-Associated Protein; B- And T-Lymphocyte Attenuator; CD272 Antigen; BTLA1; CD272
- Gene ID
- 151888
- UniProt ID
- Q7Z6A9
- Long Name
- B And T Lymphocyte Associated
- Cellular Localization
- Cell membrane; Membrane
- Post Translation Modifications
- Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.1 Publication
N-glycosylated.
- Protein Refseq
- XP_011510749.1; XP_016861237.1; XP_047303452.1; XP_054201326.1; XP_054201327.1
- Function
- Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006).
May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044).
In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
See other products for "Clone Icatolimab"
- CAT
- Product Name
See other products for "BTLA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1309CL | Human Anti-BTLA Recombinant Antibody (TAB-1309CL) | Inhib | Human IgG |
| TAB-1310CL | Human Anti-BTLA Recombinant Antibody (TAB-1310CL) | Block | Human IgG |
| TAB-1311CL | Human Anti-BTLA Recombinant Antibody (TAB-1311CL) | ELISA | Human IgG1 |
| TAB-1309CL-S(P) | Human Anti-BTLA Recombinant Antibody; scFv Fragment (TAB-1309CL-S(P)) | ELISA | Human scFv |
| TAB-1310CL-S(P) | Human Anti-BTLA Recombinant Antibody; scFv Fragment (TAB-1310CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-074CQ | Mouse Anti-BTLA Recombinant Antibody (clone PJ196) | Block, FC | Mouse IgG1 |
| NEUT-075CQ | Hamster Anti-BTLA Recombinant Antibody (clone 6A6) | FC, IP, Block | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-076CQ | Mouse Anti-BTLA Recombinant Antibody (clone 6F7) | FC, FuncS, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1605LY-S(P) | Human Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-1605LY-S(P)) | ELISA, FC | Humanized scfv |
| HPAB-M0448-YC-S(P) | Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-M0448-YC-S(P)) | FC | Mouse scFv |
| HPAB-0194-WJ-S(P) | Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-0194-WJ-S(P)) | ELISA, FC, WB, Neut | Mouse scFv |
| HPAB-0195-WJ-S(P) | Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-0195-WJ-S(P)) | ELISA, FC, WB, Neut | Mouse scFv |
| HPAB-0196-WJ-S(P) | Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-0196-WJ-S(P)) | ELISA, FC, WB, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1605LY-F(E) | Human Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-1605LY-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-M0448-YC-F(E) | Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-M0448-YC-F(E)) | FC | Mouse Fab |
| HPAB-0194-WJ-F(E) | Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-0194-WJ-F(E)) | ELISA, FC, WB, Neut | Mouse Fab |
| HPAB-0195-WJ-F(E) | Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-0195-WJ-F(E)) | ELISA, FC, WB, Neut | Mouse Fab |
| HPAB-0196-WJ-F(E) | Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-0196-WJ-F(E)) | ELISA, FC, WB, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-025CQ | Rat Anti-BTLA Recombinant Antibody (FN-025CQ) | FC, ELISA, FuncS | Rat IgG1 |
| FN-035CQ | Mouse Anti-BTLA Recombinant Antibody (clone ANC6E9) | ELISA, FC, FuncS | Mouse IgG1, κ |
| FN-079CQ | Mouse Anti-BTLA Recombinant Antibody (clone 8F4) | FC | Mouse IgG1, κ |
| VS-0723-WK43 | Human Anti-BTLA Recombinant Antibody (clone Icatolimab) | ELISA, FC | Chimeric (mouse/human) IgG4 |
| VS-0923-FY23 | Recombinant Mouse Anti-BTLA Antibody (VS-0923-FY23) | ELISA, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY6 | CytoStream™ Mouse Anti-BTLA Recombinant Antibody (VS-0225-XY6) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC609 | Recombinant Anti-BTLA Vesicular Antibody, EV Displayed (VS-0425-YC609) | ELISA, FC, SPR, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY855 | Anti-BTLA Immunohistochemistry Kit | IHC |
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