Human Anti-BTLA (clone icatolimab) scFv-Fc Chimera

CAT#: VS-0325-FY62

Anti-BTLA scFv-Fc antibody is a genetically engineered fusion protein that combines a single-chain variable fragment (scFv) of an antibody specific to B and T Lymphocyte Attenuator (BTLA) with the Fc region of an immunoglobulin (IgG). This design allows the antibody to maintain specificity for BTLA while gaining the functional properties associated with the Fc domain, such as increased stability and enhanced effector functions.

Gene Expression
Figure 1 IHC staining of human spleen Figure 2 Tonsil Figure 3 Lymph node Figure 4 RNA cell line category: Cell line enhanced (U-698)

Specifications

  • Immunogen
  • Recombinant human BTLA protein.
  • Host Species
  • Human
  • Type
  • Human IgG4, scFv-Fc
  • Specificity
  • Human BTLA
  • Species Reactivity
  • Human
  • Clone
  • icatolimab
  • Applications
  • ELISA, Flow Cytometry
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • ELISA: 1:5000-10000
    Flow Cytometry: 1:100

Target

  • Alternative Names
  • B And T Lymphocyte Associated; B- And T-Lymphocyte-Associated Protein; B- And T-Lymphocyte Attenuator; CD272 Antigen; BTLA1; CD272
  • Long Name
  • B And T Lymphocyte Associated
  • Cellular Localization
  • Cell membrane; Membrane
  • Post Translation Modifications
  • Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.1 Publication
    N-glycosylated.
  • Function
  • Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006).
    May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044).
    In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
Inquiry
Navs

Customer Review

Submit a review or a question

There are currently no Customer reviews or questions for VS-0325-FY62. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Article title:
DOI/PubMed URL:
Email:
Name:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Secondary Antibody

See other products for "Clone Icatolimab"

See other products for "BTLA"

Select a product category from the dropdown menu below to view related products.

CAT Product Name Application Type
NEUT-074CQ Mouse Anti-BTLA Recombinant Antibody (clone PJ196) Block, FC Mouse IgG1
NEUT-075CQ Hamster Anti-BTLA Recombinant Antibody (clone 6A6) FC, IP, Block Hamster IgG
CAT Product Name Application Type
NEUT-076CQ Mouse Anti-BTLA Recombinant Antibody (clone 6F7) FC, FuncS, Neut Mouse IgG1, κ
CAT Product Name Application Type
VS-0225-XY6 CytoStream™ Mouse Anti-BTLA Recombinant Antibody (VS-0225-XY6) FC Mouse IgG1, kappa
CAT Product Name Application Type
VS-0425-YC609 Recombinant Anti-BTLA Vesicular Antibody, EV Displayed (VS-0425-YC609) ELISA, FC, SPR, Neut, Cell-uptake
CAT Product Name Application Type
VS-0525-XY855 Anti-BTLA Immunohistochemistry Kit IHC
Specific Inquiry
Go to compare Add to compare

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare