Human Anti-BTLA (clone icatolimab) scFv-Fc Chimera (CAT#: VS-0325-FY62)
Anti-BTLA scFv-Fc antibody is a genetically engineered fusion protein that combines a single-chain variable fragment (scFv) of an antibody specific to B and T Lymphocyte Attenuator (BTLA) with the Fc region of an immunoglobulin (IgG). This design allows the antibody to maintain specificity for BTLA while gaining the functional properties associated with the Fc domain, such as increased stability and enhanced effector functions.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human spleen
(Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in a subset of cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47211/ihc_selected.jpg
(Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in a subset of cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47211/ihc_selected.jpg
Figure 2 Tonsil
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62029/ihc_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62029/ihc_selected.jpg
Figure 3 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62029/148776_A_8_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62029/148776_A_8_8.jpg
Figure 4 RNA cell line category: Cell line enhanced (U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186265-BTLA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186265-BTLA
Specifications
- Immunogen
- Recombinant human BTLA protein.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human BTLA
- Species Reactivity
- Human
- Clone
- icatolimab
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 1:5000-10000
Flow Cytometry: 1:100
Target
- Alternative Names
- B And T Lymphocyte Associated; B- And T-Lymphocyte-Associated Protein; B- And T-Lymphocyte Attenuator; CD272 Antigen; BTLA1; CD272
- Gene ID
- 151888
- UniProt ID
- Q7Z6A9
- Long Name
- B And T Lymphocyte Associated
- Cellular Localization
- Cell membrane; Membrane
- Post Translation Modifications
- Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.1 Publication
N-glycosylated.
- Protein Refseq
- XP_011510749.1; XP_016861237.1; XP_047303452.1; XP_054201326.1; XP_054201327.1
- Function
- Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006).
May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044).
In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1309CL | Human Anti-BTLA Recombinant Antibody (TAB-1309CL) | Inhib | Human IgG |
| TAB-1310CL | Human Anti-BTLA Recombinant Antibody (TAB-1310CL) | Block | Human IgG |
| TAB-1311CL | Human Anti-BTLA Recombinant Antibody (TAB-1311CL) | ELISA | Human IgG1 |
| TAB-1309CL-F(E) | Human Anti-BTLA Recombinant Antibody; Fab Fragment (TAB-1309CL-F(E)) | ELISA | Human Fab |
| TAB-1310CL-F(E) | Human Anti-BTLA Recombinant Antibody; Fab Fragment (TAB-1310CL-F(E)) | ELISA | Human Fab |
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