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    AbPlus™ Anti-CALCRL Magnetic Beads (VS-0424-XY38) (CAT#: VS-0424-XY38)

    The AbPlus Anti-CALCRL Magnetic Beads (VS-0424-XY38) is an innovative affinity resin which is bound with anti-CALCRL specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of CALCRL protein under native and denaturing conditions.

    Specific Inquiry
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46515/1057_C8_1_selected.jpg
    Figure 2 IHC staining of human skin
    Figure 2 IHC staining of human skin
    (Immunohistochemical staining of human skin shows strong cytoplasmic positivity in epidermal cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/ihc_selected.jpg
    Figure 3 IF staining of human cell line AF22
    Figure 3 IF staining of human cell line AF22
    (Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46515/1595_A10_2_blue_red_green.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Neuronal cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Neuropil
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_B_7_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Glandular cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous nuclear
    Peripheral nerve/ganglion
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_7_3.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_7_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Leydig cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_6_6.jpg
    Figure 8 Skin
    Figure 8 Skin
    (Fibroblasts
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Keratinocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Langerhans
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Melanocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_B_8_1.jpg

    Specifications

    • Applications
    • Immunoprecipitation, Protein Purification
    • Matrix
    • Magrose bead (> 50 μmol/mL gel)
    • Bead Ligand
    • Anti-CALCRL specific antibody
    • Target
    • CALCRL
    • Target Species
    • Human
    • Bead Capacity
    • 20-30 mg/mL binding antibody
    • Bead size
    • 10-37 μm
    • Stability
    • pH 2-14
    • Format
    • 20% Suspension
    • Buffer
    • PBS, pH 7.4, with 1% BSA
    • Preservative
    • 0.03% Proclin 300
    • Storage
    • Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

    Applications

    • Application Notes
    • The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

    Target

    • Introduction
    • CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include Pheochromocytoma and Migraine With Or Without Aura 1. Among its related pathways are Peptide ligand-binding receptors and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and protein transporter activity. An important paralog of this gene is CALCR.
    • Alternative Names
    • CALCRL; calcitonin receptor-like; CRLR; CGRPR; calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; calcitonin receptor-like receptor

    Downloads

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    Single Domain Antibody Products IgG Antibody Products ScFv Antibody Products Human Antibody Products ADCC Enhanced Antibody Products Fab Antibody Products Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    NAB-338-VHH Recombinant Anti-Human CALCRL VHH Single Domain Antibody IHC, IP, FC, Neut, FUNC Llama VHH

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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