Recombinant Anti-CALCRL Vesicular Antibody, EV Displayed (VS-0425-YC285)
CAT#: VS-0425-YC285
The Recombinant Anti-CALCRL Vesicular Antibody, EV Displayed (VS-0425-YC285) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CALCRL-expressed cells or tissues. The CALCRL is a GPCR associated with conditions such as pheochromocytoma and functions in peptide receptor pathways related to calcitonin receptors.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46515/1057_C8_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human skin
Immunohistochemical staining of human skin shows strong cytoplasmic positivity in epidermal cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46515/1595_A10_2_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_A_6_6.jpg
Normal Tissue
Figure 8 Skin
Fibroblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Langerhans
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8070/21164_B_8_1.jpg
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CALCRL
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Calcitonin receptor like receptor
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Plasma membrane
- Introduction
- CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include Pheochromocytoma and Migraine With Or Without Aura 1. Among its related pathways are Peptide ligand-binding receptors and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and protein transporter activity. An important paralog of this gene is CALCR.
- Alternative Names
- CGRPR, CRLR
- Gene ID
- 10203
- UniProt ID
- Q16602
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Datasheet
MSDS
COA
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See other products for "CALCRL"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-338-VHH | Recombinant Anti-Human CALCRL VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3237z | Mouse Anti-CALCRL Recombinant Antibody (MOB-3237z) | IHC, ICC | Mouse IgG2a |
| HPAB-AP010-YC | Human Anti-CALCRL Recombinant Antibody (HPAB-AP010-YC) | FC, Block, Neut | Human IgG |
| HPAB-AP011-YC | Human Anti-CALCRL Recombinant Antibody (HPAB-AP011-YC) | FC, Block, Neut | Human IgG |
| HPAB-AP012-YC | Human Anti-CALCRL Recombinant Antibody (HPAB-AP012-YC) | FC, Block, Neut | Human IgG |
| HPAB-AP013-YC | Human Anti-CALCRL Recombinant Antibody (HPAB-AP013-YC) | FC, Block, Neut | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3237z-F(E) | Recombinant Anti-Human CALCRL Antibody Fab Fragment | IF, FuncS | Fab |
| HPAB-AP010-YC-F(E) | Human Anti-CALCRL Recombinant Antibody; Fab Fragment (HPAB-AP010-YC-F(E)) | FC, Block, Neut | Human Fab |
| HPAB-AP011-YC-F(E) | Human Anti-CALCRL Recombinant Antibody; Fab Fragment (HPAB-AP011-YC-F(E)) | FC, Block, Neut | Human Fab |
| HPAB-AP012-YC-F(E) | Human Anti-CALCRL Recombinant Antibody; Fab Fragment (HPAB-AP012-YC-F(E)) | FC, Block, Neut | Human Fab |
| HPAB-AP013-YC-F(E) | Human Anti-CALCRL Recombinant Antibody; Fab Fragment (HPAB-AP013-YC-F(E)) | FC, Block, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3237z-S(P) | Recombinant Anti-Human CALCRL Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| HPAB-AP010-YC-S(P) | Human Anti-CALCRL Recombinant Antibody; scFv Fragment (HPAB-AP010-YC-S(P)) | FC, Block, Neut | Human scFv |
| HPAB-AP011-YC-S(P) | Human Anti-CALCRL Recombinant Antibody; scFv Fragment (HPAB-AP011-YC-S(P)) | FC, Block, Neut | Human scFv |
| HPAB-AP012-YC-S(P) | Human Anti-CALCRL Recombinant Antibody; scFv Fragment (HPAB-AP012-YC-S(P)) | FC, Block, Neut | Human scFv |
| HPAB-AP013-YC-S(P) | Human Anti-CALCRL Recombinant Antibody; scFv Fragment (HPAB-AP013-YC-S(P)) | FC, Block, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-091CL | Human Anti-CALCRL Recombinant Antibody (TAB-091CL) | PK, IP, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-087CL | Afuco™ Anti-CALCRL Recombinant Antibody (AFC-087CL), ADCC Enhanced | ELISA, WB | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY38 | AbPlus™ Anti-CALCRL Magnetic Beads (VS-0424-XY38) | IP, Protein Purification |
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