SmartAb™ Recombinant Anti-CCL22 pH-dependent Antibody (Clone MOR08378_g5-51_g2a2)
CAT#: VS-0825-YC32
The anti-CCL22 pH-dependent antibody (clone MOR08378_g5-51_g2a2) targets human CCL21 in a pH-dependent manner, with its affinity remaining high at neutral pH but weakening at a lower pH, such as within the acidic environment of endosomes. The anti-CCL21 acid-switched antibody was engineered by incorporating histidine residues into its variable regions. The introduction of histidine substitutions within its Complementarity-Determining Regions (CDRs) enables pH-responsive antigen binding, which leads to enhanced CCL21 clearance. The antibody operates in a cyclical manner, binding CCL21 in the extracellular fluid and releasing it in acidified endosomes. Human CCL21, also known as Secondary Lymphoid Tissue Chemokine (SLC), is a chemokine that directs T-cells and dendritic cells to lymph nodes. It is crucial for the organization and function of lymphoid tissues and is involved in both normal immune surveillance and inflammatory diseases.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102962-CCL22
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human CCL21
- Species Reactivity
- Human
- Clone
- MOR08378_g5-51_g2a2
- Applications
- ELISA
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
- Alternative Names
- CCL21; chemokine (C-C motif) ligand 21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21; C-C motif chemokine 21; beta chemokine exodus-3; secondary lymphoid tissue chemokine; Efficient Chemoattractant for Lymphocytes; small inducible cytokine subfamily A (Cys-Cys),j.
- Gene ID
- 6367
- UniProt ID
- O00586
- Long Name
- C-C Motif Chemokine Ligand 22
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone MOR08378_g5-51_g2a2"
- CAT
- Product Name
See other products for "CCL22"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1496CL | Anti-Human CCL22 Recombinant Antibody (MOR08378_g5-51_g2a2) | FuncS | Fully human antibody |
| TAB-1496CL-S(P) | Anti-Human CCL22 Recombinant Antibody scFv Fragment (MOR08378_g5-51_g2a2) | FuncS | Fully human antibody |
| TAB-1496CL-F(E) | Anti-Human CCL22 Recombinant Antibody Fab Fragment (MOR08378_g5-51_g2a2) | FuncS | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1457MZ | Recombinant Mouse Anti-Human CCL22 Antibody | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-174CQ | Mouse Anti-CCL22 Recombinant Antibody (clone CBL003) | Neut, WB | Mouse IgG2 |
| NEUT-175CQ | Mouse Anti-CCL22 Recombinant Antibody (clone CBL477) | WB, ELISA(Cap), Neut | Mouse IgG2b |
| NEUT-176CQ | Mouse Anti-CCL22 Recombinant Antibody (clone MM0147-13G44) | WB, Neut | Mouse IgG2 |
| NEUT-177CQ | Rat Anti-CCL22 Recombinant Antibody (clone CBL854) | Neut, WB | Rat IgG2 |
| NEUT-178CQ | Rat Anti-CCL22 Recombinant Antibody (clone CBL567) | ELISA(Cap), Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0506 | Hi-Affi™ Rabbit Anti-CCL22 Recombinant Antibody (clone DS506AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY14 | Human Anti-CCL22 scFv-Fc Chimera (VS-0425-FY14) | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1061 | Anti-CCL22 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC48 | Recombinant Anti-CCL22 Eliminating Antibody, pH-Sensitive (MOR08378_g5-51_g2a2 var.) | Antigen-Sweeping In Vivo. | Human IgG |
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