Human Anti-CCL22 scFv-Fc Chimera (VS-0425-FY14) (CAT#: VS-0425-FY14)
The anti-CCL22 scFv-Fc is a recombinant antibody designed to specifically target and neutralize CCL22, a chemokine involved in immune response and tumor progression. This fusion protein combines the single-chain variable fragment (scFv) with an Fc region, enhancing its stability and efficacy in vivo. It holds potential for applications in cancer immunotherapy and inflammatory diseases by modulating immune cell recruitment. Additionally, its high specificity minimizes off-target effects, making it a promising candidate for therapeutic development.
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RNA Expression
Figure 1 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102962-CCL22
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102962-CCL22
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CCL22
- Species Reactivity
- Human
- Applications
- Inhibition
- Related Disease
- Eosinophilic Pneumonia and Dermatitis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- C-C Motif Chemokine Ligand 22; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22; Chemokine (C-C Motif) Ligand 22; Macrophage-Derived Chemokine; CC Chemokine STCP-1; MDC(1-69); SCYA22; MDC; Stimulated T Cell Chemotactic Protein 1
- Gene ID
- 6367
- UniProt ID
- O00626
- Long Name
- C-C Motif Chemokine Ligand 22
- Sequence Similarities
- Belongs to the intercrine beta (chemokine CC) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_047290405.1; XP_047290406.1; XP_054169574.1; XP_054169575.1; NP_002981.2
- Function
- May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology.
Chemotactic for monocytes, dendritic cells and natural killer cells.
Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes.
Binds to CCR4.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
IgG Antibody Products
Neutralizing Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1496CL | Anti-Human CCL22 Recombinant Antibody (MOR08378_g5-51_g2a2) | FuncS | Fully human antibody |
| TAB-1496CL-S(P) | Anti-Human CCL22 Recombinant Antibody scFv Fragment (MOR08378_g5-51_g2a2) | FuncS | Fully human antibody |
| TAB-1496CL-F(E) | Anti-Human CCL22 Recombinant Antibody Fab Fragment (MOR08378_g5-51_g2a2) | FuncS | Fully human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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