Anti-CD58 Antibody Prodrug, Protease Activated (1E6)
CAT#: VS-1025-YC193
The Anti-CD58 Antibody Prodrug, Protease Activated (1E6) is an antibody prodrug comprised of a recombinant mouse antibody targeting human CD58, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CD58 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CD58 effectively. CD58 (LFA-3) is a cell adhesion molecule on antigen-presenting cells that helps initiate T-cell activation. Its loss of expression on tumor cells (e.g., Hodgkin lymphoma) is a mechanism of immune evasion, as it prevents the effective interaction required for T-cell killing.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116815-CD58
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human CD58
- Target
- CD58
- Species Reactivity
- Human
- Isotype
- IgG1
- Clone
- 1E6
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- CD58 (CD58 Molecule) is a Protein Coding gene. Diseases associated with CD58 include Whipple Disease and Oral Lichen Planus. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding.
- Alternative Names
- CD58 Molecule; Surface Glycoprotein LFA-3; LFA3; AG3; Lymphocyte Function-Associated Antigen 3; CD58 Antigen
- Gene ID
- 965
- UniProt ID
- P19256
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Datasheet
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COA
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See other products for "Clone 1E6"
- CAT
- Product Name
See other products for "CD58"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1415z | Mouse Anti-CD58 Recombinant Antibody (clone 40C4) | WB, IP, FC | Mouse IgG1 |
| MOB-0052MZ | Recombinant Mouse Anti-Human CD58 Antibody (clone NEM-64) | FC, IP, WB | Mouse antibody |
| FN-063CQ | Mouse Anti-CD58 Recombinant Antibody (clone TS2) | FC, FuncS | Mouse IgG1 |
| HPAB-1837-FY | Mouse Anti-CD58 Recombinant Antibody (clone 1E6) | Inhib, FC | Mouse IgG1 |
| VS2-QX19 | Mouse Anti-CD58 Recombinant Antibody (clone BRIC 5) | IB | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-396CQ | Mouse Anti-CD58 Recombinant Antibody (clone TS2/9) | Block, ELISA, FC, ICC, IF, IHC, IHC-Fr, IP, Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0571 | Hi-Affi™ Rabbit Anti-CD58 Recombinant Antibody (clone DS571AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1837-FY-F(E) | Mouse Anti-CD58 Recombinant Antibody (clone 1E6); scFv Fragment | FC, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1837-FY-S(P) | Mouse Anti-CD58 Recombinant Antibody (clone 1E6); Fab Fragment | FC, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC604 | AbPlus™ Anti-CD58 Magnetic Beads (VS-0724-YC604) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC170 | CytoStream™ Rabbit Anti-CD58 Recombinant Antibody (VS13-YC170) | WB, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC507 | Recombinant Anti-CD58 Vesicular Antibody, EV Displayed (VS-0425-YC507) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1202 | Anti-CD58 Immunohistochemistry Kit | IHC |
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