Rabbit Anti-CDX2 Recombinant Antibody (clone R05-3C9) (CAT#: VS3-XY3310)
The product is a recombinant rabbit antibody against CDX2 (Caudal type homeobox 2), which binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. It specifically reacts with human, mouse and rat CDX2. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45669/if_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45669/if_selected.jpg
Figure 2 Duodenum
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Paneth cells
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_9_2.jpg
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Paneth cells
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_9_2.jpg
Figure 3 Colon
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_8_3.jpg
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_8_3.jpg
Figure 4 RNA cell line category: Group enriched (CACO-2, CAPAN-2, HEK93)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165556-CDX2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165556-CDX2
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CDX2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-3C9
- Applications
- WB, IHC-P, ICC, IF, FC
- Related Disease
- Sirenomelia; Anorectal Malformation
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- CDX3; CDX-3; CDX2/AS
- Gene ID
- 1045
- UniProt ID
- Q99626
- Long Name
- Caudal type homeobox 2
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
- Protein Refseq
- XP_011533178.1; XP_011533177.1
- Function
- Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CDX2"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-285 | Human Anti-CDX2 Recombinant Antibody (clone T46) | IP, ELISA | Human IgG |
| MOB-0297MZ | Recombinant Mouse Anti-Human Caudal Type Homeobox 2 Antibody (clone EAK-CDX3) | IHC | Mouse antibody |
| VS3-FY365 | Recombinant Mouse Anti-CDX2 Antibody (clone 5B4C1) | ELISA, IHC, FC | Mouse IgG1 |
| VS3-FY366 | Recombinant Mouse Anti-CDX2 Antibody (clone 5C11H10) | ELISA, IHC, ICC, FC | Mouse IgG1 |
| VS3-FY367 | Recombinant Mouse Anti-CDX2 Antibody (clone 6E8-8D9-3C4) | IHC-P | Mouse IgG3 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0646 | Hi-Affi™ Rabbit Anti-CDX2 Recombinant Antibody (clone DS646AB) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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