Rabbit Anti-CDX2 Recombinant Antibody (clone R05-3C9) (CAT#: VS3-XY3310)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat CDX2

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R05-3C9

• Applications
• WB, IHC-P, ICC, IF, FC

• Related Disease
• Sirenomelia; Anorectal Malformation

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IF: 1/50-1/200
  FC: 1/50-1/100

• Alternative Names
• CDX3; CDX-3; CDX2/AS

• Gene ID
• 1045

• UniProt ID
• Q99626

• Long Name
• Caudal type homeobox 2

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.

• Protein Refseq
• XP_011533178.1; XP_011533177.1

• Function
• Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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