Rabbit Anti-CDX2 Recombinant Antibody (clone R05-3C9)
CAT#: VS3-XY3310
The product is a recombinant rabbit antibody against CDX2 (Caudal type homeobox 2), which binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. It specifically reacts with human, mouse and rat CDX2. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45669/if_selected.jpg
Normal Tissue
Figure 2 Duodenum
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Paneth cells
Staining:High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_9_2.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_8_3.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (CACO-2, CAPAN-2, HEK93)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165556-CDX2
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CDX2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-3C9
- Applications
- WB, IHC-P, ICC, IF, FC
- Related Disease
- Sirenomelia; Anorectal Malformation
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- CDX3; CDX-3; CDX2/AS
- Gene ID
- 1045
- UniProt ID
- Q99626
- Long Name
- Caudal type homeobox 2
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
- Protein Refseq
- XP_011533178.1; XP_011533177.1
- Function
- Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CDX2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0646 | Hi-Affi™ Rabbit Anti-CDX2 Recombinant Antibody (clone DS646AB) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0349-CN | Rabbit Anti-CDX2 Recombinant Antibody (clone SY09-02) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-QX223 | Mouse Anti-CDX2 Recombinant Antibody (clone 4B9-B12-E9) | WB, IP, ICC | Mouse IgG2b |
| VS3-WK1114 | Mouse Anti-CDX2 Recombinant Antibody (VS3-WK1114) | WB, IHC | Mouse IgG |
| VS3-WK1115 | Mouse Anti-CDX2 Recombinant Antibody (clone ABT-CDX2) | IHC-P | Mouse IgG1, κ |
| VS3-WK1116 | Mouse Anti-CDX2 Recombinant Antibody (clone PT0062) | IHC-P | Mouse IgG3, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY61 | AbPlus™ Anti-CDX2 Magnetic Beads (4B9-B12-E9) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY418 | Anti-CDX2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1352 | Anti-Mouse CDX2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1351 | Anti-Human CDX2 Immunohistochemistry Kit | IHC |
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