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    Rabbit Anti-CDX2 Recombinant Antibody (clone R05-3C9) (CAT#: VS3-XY3310)

    The product is a recombinant rabbit antibody against CDX2 (Caudal type homeobox 2), which binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. It specifically reacts with human, mouse and rat CDX2. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45669/if_selected.jpg
    Normal Tissue
    Figure 2 Duodenum
    Figure 2 Duodenum
    (Endocrine cells
    Staining:High
    Intensity: Strong
    Enterocytes
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Goblet cells
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Paneth cells
    Staining:High
    Intensity: Strong)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_9_2.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endocrine cells
    Staining:High
    Intensity: Strong
    Enterocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Goblet cells
    Staining:High
    Intensity: Strong
    Quantity:>75%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_8_3.jpg
    RNA Expression
    Figure 4 RNA cell line category: Group enriched (CACO-2, CAPAN-2, HEK93)
    Figure 4 RNA cell line category: Group enriched (CACO-2, CAPAN-2, HEK93)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165556-CDX2

    Specifications

    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human, Mouse and Rat CDX2
    • Species Reactivity
    • Human, Mouse, Rat
    • Clone
    • R05-3C9
    • Applications
    • WB, IHC-P, ICC, IF, FC
    • Related Disease
    • Sirenomelia; Anorectal Malformation

    Product Property

    • Clonality
    • Monoclonal
    • Aggregation
    • < 5%
    • Format
    • Liquid
    • Buffer
    • PBS (pH 7.4), 150 mM NaCl and 50% glycerol
    • Preservative
    • 0.02% sodium azide
    • Storage
    • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • WB: 1/500-1/1000
      IHC: 1/50-1/100
      IF: 1/50-1/200
      FC: 1/50-1/100

    Target

    • Alternative Names
    • CDX3; CDX-3; CDX2/AS
    • Long Name
    • Caudal type homeobox 2
    • Cellular Localization
    • Nucleus
    • Post Translation Modifications
    • Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
    • Function
    • Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2.

    Recommended Products

    Isotype Control

    Recommended Dilution Buffer

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "CDX2"

    Select a product category from the dropdown menu below to view related products.
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    Rabbit Monoclonal Antibody Products IgG Antibody Products Antibody Magnetic Beads IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
    CAT Product Name Application Type
    MOR-0646 Hi-Affi™ Rabbit Anti-CDX2 Recombinant Antibody (clone DS646AB) FC, ICC, IF, IHC-P, WB Rabbit IgG

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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