Mouse Anti-CFH Recombinant Antibody (clone VS0724W2) (CAT#: VS-0724-FY7)
This is a mouse recombinant antibody with high affinity for human CFH. VS0724W2 binds to amino acids 1110-1122 of CFH. CFH prevents complement-mediated cytotoxicity (CDC) by inhibiting the formation of the lytic membrane attack complex on its own surface.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows strong plasma positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49176/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows strong plasma positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49176/ihc_selected.jpg
Figure 2 IHC staining of human ovary
(Immunohistochemical staining of human ovary shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53326/ihc_selected.jpg
(Immunohistochemical staining of human ovary shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53326/ihc_selected.jpg
Figure 3 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/ihc_selected.jpg
Figure 4 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/37049_A_8_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/37049_A_8_3.jpg
Figure 5 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/37049_A_9_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/37049_A_9_5.jpg
Figure 6 Testis
(Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/37049_A_6_6.jpg
(Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/37049_A_6_6.jpg
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HSkMC, hTERT-RPE1, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000000971-CFH
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000000971-CFH
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human CFH
- Species Reactivity
- Human
- Clone
- VS0724W2
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Complement Factor H Deficiency and Macular Degeneration, Age-Related, 4
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow cytometry: 300 μg/mL
Target
- Alternative Names
- Complement Factor H; Age-Related Maculopathy Susceptibility 1; H Factor 2 (Complement); H Factor 1 (Complement); Beta-1H; HF1; HF2; HF; Adrenomedullin Binding Protein; Beta-1-H-Globulin; Factor H-Like 1
- Gene ID
- 3075
- UniProt ID
- P08603
- Long Name
- Complement Factor H
- Cellular Localization
- Secreted
- Post Translation Modifications
- Sulfated on tyrosine residues.
Glycosylation at Asn217, Asn529, Asn718, Asn802, Asn822, Asn882, Asn911, Asn1029, and Asn1095
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect CFAH
Glycosylation from GlyGen (P08603) 9 sites, 66 N-linked glycans (9 sites)
- Protein Refseq
- NP_000177.2; NP_001014975.1
- Function
- Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces.
Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop.
As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1578z | Mouse Anti-CFH Recombinant Antibody (clone 31G10) | ELISA, IHC, IP | Mouse IgG2b, κ |
| MRO-0563-CN | Rabbit Anti-CFH Recombinant Antibody (clone JA52-13) | WB, IF | Rabbit IgG |
| HPAB-N0047-YC | Human Anti-CFH Recombinant Antibody (clone TRN-1006) | ELISA, Inhib | Human IgG |
| HPAB-0512-YJ | Human Anti-CFH Recombinant Antibody (HPAB-0512-YJ) | ELISA, DB, FuncS | Human IgG3 |
| VS13-YC214 | Rabbit Anti-CFH Recombinant Antibody (VS13-YC214) | WB, ICC, IF | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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