Mouse Anti-CFH Recombinant Antibody (clone VS0724W2)
CAT#: VS-0724-FY7
This is a mouse recombinant antibody with high affinity for human CFH. VS0724W2 binds to amino acids 1110-1122 of CFH. CFH prevents complement-mediated cytotoxicity (CDC) by inhibiting the formation of the lytic membrane attack complex on its own surface.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong plasma positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49176/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human ovary
Immunohistochemical staining of human ovary shows distinct positivity in plasma.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53326/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows distinct positivity in plasma.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/ihc_selected.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/37049_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/37049_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16385/37049_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HSkMC, hTERT-RPE1, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000000971-CFH
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human CFH
- Species Reactivity
- Human
- Clone
- VS0724W2
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Complement Factor H Deficiency and Macular Degeneration, Age-Related, 4
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow cytometry: 300 μg/mL
Target
- Alternative Names
- Complement Factor H; Age-Related Maculopathy Susceptibility 1; H Factor 2 (Complement); H Factor 1 (Complement); Beta-1H; HF1; HF2; HF; Adrenomedullin Binding Protein; Beta-1-H-Globulin; Factor H-Like 1
- Gene ID
- 3075
- UniProt ID
- P08603
- Long Name
- Complement Factor H
- Cellular Localization
- Secreted
- Post Translation Modifications
- Sulfated on tyrosine residues.
Glycosylation at Asn217, Asn529, Asn718, Asn802, Asn822, Asn882, Asn911, Asn1029, and Asn1095
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect CFAH
Glycosylation from GlyGen (P08603) 9 sites, 66 N-linked glycans (9 sites)
- Protein Refseq
- NP_000177.2; NP_001014975.1
- Function
- Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces.
Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop.
As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CFH"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-063MZ | Mouse Anti-CFH Recombinant Antibody (TAB-063MZ) | ELISA, Inhib, IF | Mouse IgG1 |
| TAB-064MZ | Mouse Anti-CFH Recombinant Antibody (TAB-064MZ) | ELISA, Inhib | Mouse IgG1 |
| TAB-063MZ-S(P) | Mouse Anti-CFH Recombinant Antibody; scFv Fragment (TAB-063MZ-S(P)) | ELISA | Mouse scFv |
| TAB-063MZ-F(E) | Mouse Anti-CFH Recombinant Antibody; Fab Fragment (TAB-063MZ-F(E)) | ELISA | Mouse Fab |
| TAB-064MZ-F(E) | Mouse Anti-CFH Recombinant Antibody; Fab Fragment (TAB-064MZ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0674 | Hi-Affi™ Rabbit Anti-CFH Recombinant Antibody (clone DS674AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4399 | PE-A*01:01/Human CFH (CSDDGFWSK) MHC Tetramer | FCM | |
| MHC-LC4400 | PE-A*11:01/Human CFH (CSDDGFWSK) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0563-CN | Rabbit Anti-CFH Recombinant Antibody (clone JA52-13) | WB, IF | Rabbit IgG |
| HPAB-0515YY | Human Anti-CFH Recombinant Antibody (HPAB-0515YY) | ELISA, FC | Human IgG1, κ |
| HPAB-0520YY | Human Anti-CFH Recombinant Antibody (HPAB-0520YY) | ELISA, FC | Human IgG1, κ |
| HPAB-0521YY | Human Anti-CFH Recombinant Antibody (HPAB-0521YY) | Inhib | Human IgG1, κ |
| FAMAB-1105CQ | Mouse Anti-CFH Recombinant Antibody (clone OX23) | IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0038-YC-S(P) | Human Anti-CFH Recombinant Antibody scFv Fragment (HPAB-M0038-YC-S(P)) | ELISA | Human scFv |
| HPAB-0512-YJ-S(P) | Human Anti-CFH Recombinant Antibody; scFv Fragment (HPAB-0512-YJ-S(P)) | ELISA, DB, FuncS | Human scFv |
| HPAB-0515YY-S(P) | Human Anti-CFH Recombinant Antibody; scFv Fragment (HPAB-0515YY-S(P)) | ELISA, FC | Human scFv |
| HPAB-0520YY-S(P) | Human Anti-CFH Recombinant Antibody; scFv Fragment (HPAB-0520YY-S(P)) | ELISA, FC | Human scFv |
| HPAB-0521YY-S(P) | Human Anti-CFH Recombinant Antibody; scFv Fragment (HPAB-0521YY-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0038-YC-F(E) | Human Anti-CFH Recombinant Antibody Fab Fragment (HPAB-M0038-YC-F(E)) | ELISA | Human Fab |
| HPAB-0512-YJ-F(E) | Human Anti-CFH Recombinant Antibody; Fab Fragment (HPAB-0512-YJ-F(E)) | ELISA, DB, FuncS | Human Fab |
| HPAB-0515YY-F(E) | Human Anti-CFH Recombinant Antibody; Fab Fragment (HPAB-0515YY-F(E)) | ELISA, FC | Human Fab |
| HPAB-0520YY-F(E) | Human Anti-CFH Recombinant Antibody; Fab Fragment (HPAB-0520YY-F(E)) | ELISA, FC | Human Fab |
| HPAB-0521YY-F(E) | Human Anti-CFH Recombinant Antibody; Fab Fragment (HPAB-0521YY-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY432 | Anti-CFH Immunohistochemistry Kit | IHC | |
| VS-0525-XY1394 | Anti-Human CFH Immunohistochemistry Kit | IHC |
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