Recombinant Anti-CGRP (AA 90-100 x Phe109/119) Biparatopic Antibody, Tandem scFv
CAT#: VS-0525-YC211
This biparatopic antibody (bpAb) binds two distinct CGRP epitopes. Its tandem scFv arms exhibit simultaneous, high-affinity binding to amino acids 90-100 (VTHRLAGLLSR) and a C-terminal region where Phe109 and Phe119 are key contributors.
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human CALCA (αCGRP) and CALCB (βCGRP)
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Epitope 1
- aa 90-100, VTHRLAGLLSR
- Epitope 2
- C-terminal region where Phe109 and Phe119 are key contributors
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, IHC, FC, IP, IF, Inhib
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Calcitonin Gene-Related Peptide
Target
- Introduction
- This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- CALCA; calcitonin related polypeptide alpha; CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I
- Gene ID
- 796
- UniProt ID
- P01258
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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