Rabbit Anti-CHRNA4 Recombinant Antibody (clone R03-1A5) (CAT#: VS3-FY2047)
This is a rabbit recombinant monoclonal antibody that detects human CHRNA4. It cross-reacts with mouse, rat, hamster. It is suitable for use in a variety of assays, including WB, IP. For detection of human CHRNA4 using immunoprecipitation, please refer to clone R03-1A5.
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WB
Figure 1 Anti-CHRNA4 Antibody (VS3-FY2047) in WB.
The Nicotinic Acetylcholine Receptor alpha 4/CHRNA4 expression in 3T3 lysates were detected using the anti-Nicotinic Acetylcholine Receptor alpha 4 by western blot assay.
WB
Figure 2 Anti-CHRNA4 Antibody (VS3-FY2047) in WB.
The Nicotinic Acetylcholine Receptor alpha 4/CHRNA4 expression in Hela, CHO-K1, C6, Ramos lysates were detected using the anti-Nicotinic Acetylcholine Receptor alpha 4/CHRNA4 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human nicotinic acetylcholine receptor α4/CHRNA4
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse, Rat, Hamster CHRNA4
- Species Reactivity
- Human, Mouse, Rat, Hamster
- Clone
- R03-1A5
- Applications
- Western Blot, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 70 kDa, while the observed molecular weight stands at 70 kDa.
- Related Disease
- Epilepsy, Nocturnal Frontal Lobe, 1 and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunoprecipitation: 1/20
Target
- Alternative Names
- Cholinergic Receptor Nicotinic Alpha 4 Subunit; Cholinergic Receptor, Nicotinic, Alpha Polypeptide 4; Cholinergic Receptor, Nicotinic, Alpha 4 (Neuronal); Cholinergic Receptor, Nicotinic Alpha 4; NACRA4; Neuronal Nicotinic Acetylcholine Receptor Alpha-4 Subunit; Acetylcholine Receptor, Nicotinic, Alpha 4 (Neuronal)
- Gene ID
- 1137
- UniProt ID
- P43681
- Sequence Similarities
- Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.
- Cellular Localization
- Cell membrane, Membrane, Postsynaptic cell membrane, Synapse
- Post Translation Modifications
- Glycosylation at Asn57, Asn174, and Asn107 (NX_P43681 [NX_P43681-1])
Modification sites at PhosphoSitePlus (P43681)
Glycosylation from GlyGen (P43681) 3 sites
- Protein Refseq
- NP_000735.1; NP_001243502.1
- Function
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3787z | Mouse Anti-CHRNA4 Recombinant Antibody (clone 19G3) | WB, ELISA | Mouse IgG1, κ |
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