


CHRNA4

Anti-CHRNA4 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA
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- Species Reactivity: Human, Mouse, Rat, Hamster
- Type: Rabbit IgG
- Application: WB, IP
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- Scaffold Name: PDZ domain
- Target: nAChRc
- Species Reactivity: Human
- Derivation: Yeast Two-hybrid
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
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For Research Use Only. Not For Clinical Use.
Background
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Intracellular, Membrane (different isoforms)
Group enriched (Horizontal cells, Hepatocytes)
Not detected in immune cells
Cell line enriched (U-2 OS)
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers (PubMed:22361591). Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The heteropentamer alpha-4-beta-2 interacts with alpha-conotoxins PnIA, GID and MII (By similarity).
Ion channel, Ligand-gated ion channel, Receptor