SmartAb™ Recombinant Anti-CLDN18 pH-dependent Antibody (VS-0825-YC374)
CAT#: VS-0825-YC374
The anti-CLDN18 pH-dependent antibody (VS-0825-YC374) is a pH-responsive antibody engineered to target human CLDN18. This pH-switched monoclonal antibody (mAb) was developed by incorporating histidine residues into its variable regions, which results in pH-biased binding to CLDN18. By leveraging the natural pH variations in different tissues and cellular compartments, this pH-responsive antibody facilitates precise targeting of CLDN18 on cells and tissues. Human CLDN18 (Claudin 18) is a tight junction protein that plays a role in forming epithelial tight junctions. One of its splice variants, CLDN18.2, is a promising therapeutic target for gastric and pancreatic cancers due to its specific expression patterns.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line OE19
Immunofluorescent staining of human cell line OE19 shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18446/1971_G5_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong membranous and cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13010/ihc_selected.jpg
Normal Tissue
Figure 3 Stomach
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13243/28279_A_2_1.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066405-CLDN18
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Specifications
- Host Species
- Chimeric (Mouse/Human)
- Type
- IgG (combining the mouse antibody's antigen-binding variable regions with a human IgG constant region)
- Specificity
- Human CLDN18
- Species Reactivity
- Human
- Applications
- ELISA
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-215-F(E) | Recombinant Anti-human CLDN18 Antibody Fab Fragment | IP, IF, FuncS | Fab |
| MHH-215-F(E) | Recombinant Human Anti-human CLDN18 Antibody Fab Fragment | WB, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-215-S(P) | Recombinant Anti-human CLDN18 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-215-S(P) | Recombinant Human Anti-human CLDN18 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-215 | Recombinant Human Anti-human CLDN18 Antibody | WB, ELISA, IHC, FuncS | IgG |
| ZG-0155J | Mouse Anti-CLDN18 Recombinant Antibody (ZG-0155J) | IHC-P, IF | Mouse IgG |
| ZG-0156J | Mouse Anti-CLDN18 Recombinant Antibody (ZG-0156J) | IHC-P, IF | Mouse IgG |
| VS3-FY389 | Recombinant Mouse Anti-CLDN18 Antibody (clone 5F3-5G6-6B3) | IHC-P | Mouse IgG1 |
| VS4-WK111 | Mouse Anti-CLDN18 Recombinant Antibody (VS4-WK111) | ELISA, IHC | Mouse IgG1, Lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4553 | Hi-Affi™ Rabbit Anti-CLDN18 Recombinant Antibody (clone TH63DS) | WB, IF, ICC, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1482 | Anti-CLDN18 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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