Mouse Anti-CLDN2 Recombinant Antibody (clone 8H11)
CAT#: VS3-WK1617
This antibody is a mouse recombinant antibody against human CLDN2, which belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. The clone 8H11 can be used in WB analysis at a dilution of 1/1000-1/2000 and IHC analysis at a dilution of 1/50-1/200.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/51548/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2609/6567_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2609/6567_A_7_3.jpg
Normal Tissue
Figure 4 High expression in gallbladder.
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2609/6567_A_4_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165376-CLDN2
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Specifications
- Immunogen
- Synthesized peptide derived from human Claudin-2
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human CLDN2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 8H11
- Applications
- WB, IHC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC: 1/50-1/200
WB: 1/1000-1/2000
Target
- Alternative Names
- Claudin 2; SP82; Claudin-2
- Gene ID
- 9075
- UniProt ID
- P57739
- Long Name
- Claudin 2
- Sequence Similarities
- Belongs to the claudin family.
- Cellular Localization
- Cell junction, tight junction, Cell membrane
- Post Translation Modifications
- The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.
- Protein Refseq
- NP_001164563.1
- Function
- Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
Isotype Control
- CAT
- Product Name
See other products for "CLDN2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1102MZ | Recombinant Mouse Anti-Human CLDN2 Antibody | WB | Mouse antibody |
| ZG-0157J | Mouse Anti-CLDN2 Recombinant Antibody (ZG-0157J) | IHC-P, IF, WB | Mouse IgG |
| VS3-QX246 | Mouse Anti-CLDN2 Recombinant Antibody (clone 9F10-2F5-7B9) | WB, IHC | Mouse IgG1 |
| VS3-QX247 | Mouse Anti-CLDN2 Recombinant Antibody (clone 2G4) | IHC | Mouse IgG1 |
| VS3-QX248 | Mouse Anti-CLDN2 Recombinant Antibody (clone 3C5) | IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0717 | Hi-Affi™ Rabbit Anti-CLDN2 Recombinant Antibody (clone DS717AB) | WB | Rabbit IgG |
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