Rabbit Anti-CLU Recombinant Antibody (clone R93-8K-4)
CAT#: VS3-FY2184
This is a rabbit recombinant monoclonal antibody that is specificity for mouse CLU. It cross-reacts with rat. The R93-8K-4 is recommended for dilution with western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/100-1/200), immunoprecipitation (dilution 1/50).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/1919_G12_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/2064_D2_1_blue_red_green.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_B_7_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_6_6.jpg
Normal Tissue
Figure 5 Epididymis
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_3_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HeLa, SK-BR-3, T-47d, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120885-CLU
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Mouse and Rat CLU
- Species Reactivity
- Mouse, Rat
- Clone
- R93-8K-4
- Applications
- Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation
- Conjugate
- Unconjugated
- MW
- The calculated weight of the target protein is approximately 52 kDa, while the observed molecular weight stands at 40kDa.
- Related Disease
- Scrapie and Anaplastic Large Cell Lymphoma
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4), 150 mM NaCl, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/100-1/200
Immunoprecipitation: 1/50
Target
- Alternative Names
- Clusterin; Testosterone-Repressed Prostate Message 2; Apolipoprotein J; Complement-Associated Protein SP-40,40; Complement Cytolysis Inhibitor; Complement Lysis Inhibitor; Sulfated Glycoprotein 2; Ku70-Binding Protein 1; NA1/NA2; TRPM-2; APO-J; APOJ; KUB1
- Gene ID
- 1191
- UniProt ID
- P10909
- Sequence Similarities
- Belongs to the clusterin family.
- Cellular Localization
- Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Microsome
- Post Translation Modifications
- Proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen (PubMed:2387851).
Proteolytic cleavage is not necessary for its chaperone activity (PubMed:25402950).
All non-secreted forms are not proteolytically cleaved (PubMed:24073260).
Chaperone activity of uncleaved forms is dependent on a non-reducing environment.
- Protein Refseq
- NP_001822.3
- Function
- Functions as extracellular chaperone that prevents aggregation of non native proteins.
Prevents stress-induced aggregation of blood plasma proteins.
Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CLU"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-690-VHH | Recombinant Anti-Human CLU VHH Single Domain Antibody | ICC, FC, WB, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2085z | Mouse Anti-CLU Recombinant Antibody (clone 25A5) | WB, IHC | Mouse IgG1 |
| HPAB-0440LY | Human Anti-CLU Recombinant Antibody (HPAB-0440LY) | ELISA, RIA, FC | Humanized IgG2 |
| FAMAB-1093CQ | Mouse Anti-CLU Recombinant Antibody (clone SAIC-43B-8) | Immuno-MRM, WB, ELISA | Mouse IgG1 |
| ZG-0619J | Rabbit Anti-CLU Recombinant Antibody (clone 2A1) | ELISA, IHC | Rabbit IgG |
| VS3-XY3320 | Rabbit Anti-CLU Recombinant Antibody (clone R07-4K8) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-178CL | Human Anti-CLU Recombinant Antibody (TAB-178CL) | FuncS, Inhib | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-533LC | Mouse Anti-CLU Recombinant Antibody (TAB-533LC) | WB | Mouse IgG |
| TAB-533LC-S(P) | Mouse Anti-CLU Recombinant Antibody; scFv Fragment (TAB-533LC-S(P)) | WB | Mouse scFv |
| TAB-533LC-F(E) | Mouse Anti-CLU Recombinant Antibody; Fab Fragment (TAB-533LC-F(E)) | WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0735 | Hi-Affi™ Rabbit Anti-CLU Recombinant Antibody (clone DS735AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-YC-S(P) | Mouse Anti-CLU Recombinant Antibody; scFv Fragment (HPAB-0203-YC-S(P)) | ELISA, FC, RIA | Mouse scFv |
| HPAB-0204-YC-S(P) | Human Anti-CLU Recombinant Antibody; scFv Fragment (HPAB-0204-YC-S(P)) | ELISA, FC, RIA | Humanized scFv |
| HPAB-0440LY-S(P) | Human Anti-CLU Recombinant Antibody; scFv Fragment (HPAB-0440LY-S(P)) | ELISA, RIA, FC | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-YC-F(E) | Mouse Anti-CLU Recombinant Antibody; Fab Fragment (HPAB-0203-YC-F(E)) | ELISA, FC, RIA | Mouse Fab |
| HPAB-0204-YC-F(E) | Human Anti-CLU Recombinant Antibody; Fab Fragment (HPAB-0204-YC-F(E)) | ELISA, FC, RIA | Humanized Fab |
| HPAB-0440LY-F(E) | Human Anti-CLU Recombinant Antibody; Fab Fragment (HPAB-0440LY-F(E)) | ELISA, RIA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1535 | Anti-CLU Immunohistochemistry Kit | IHC |
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