Anti-CLU Recombinant Antibody Products

Loading...

Anti-CLU Products

+ Filter

Loading...

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs is a world-class supplier of neurobiology and oncology research antibodies. Clusterin (CLU) is a secreted, multi-functional chaperone protein linked to a broad range of biological functions, including apoptosis, lipid transport, protein degradation, and stress response. Creative’s high-quality antibodies support your research into its context-dependent function in Alzheimer’s disease progression, cancer cell survival, and autoimmune disease.

CLU: A Multifunctional Extracellular Chaperone

Clusterin, also known as Apolipoprotein J, is a highly conserved glycoprotein and one of the most abundant secreted proteins in the body. It acts as an extracellular chaperone that can associate with misfolded or stressed proteins to block their aggregation and promote clearance. Clusterin’s disease association is complex and context dependent. As a major genetic risk factor for Alzheimer’s disease, it localizes to amyloid plaques, where it likely attempts to counteract protein aggregation. Clusterin is a key mediator of the cancer cell stress response and becomes upregulated in response to therapy (chemo, radiation), where it acts as a pro-survival factor in the tumor microenvironment to prevent apoptosis.

Alternative Names

CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2; clusterin; aging-associated protein 4; apolipoprotein J; complement cytolysis inhibitor; complement lysis inhibitor; complement-associated protein SP-40,40; epididymis secretory sperm binding protein; ku70-binding protein 1; sulfated glycoprotein 2; testosterone-repressed prostate message 2

Background

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.

Anti-CLU rAb Products

Our anti-CLU recombinant antibodies are designed to have high affinity and specificity. They are validated for specific and sensitive detection of secreted Clusterin in biological fluids (plasma, CSF) and in cell culture supernatants. Optimized for key applications including ELISA for quantification, Western Blot, and IHC on tumor and brain tissue, our rAbs are the premium choice for complex disease research.

Table 1. Featured anti-CLU recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs’ commitment to scientific excellence is unwavering. The production of our anti-CLU recombinant antibodies is supported by a comprehensive quality assurance program. Each lot of antibodies is extensively validated for purity, binding kinetics, and consistent performance in application to ensure you receive a reliable, high quality reagent.

Customer Reviews

Excellent

D**en
Mouse Anti-CLU Recombinant Antibody (clone SAIC-43B-8)

The quality of Creative Biolabs’ reagents is exceptional. Their anti-CLU antibody has provided consistent, reliable data throughout our project on this complex chaperone protein.

13/Sep/2024

rAb Production

Creative Biolabs leverages state-of-the-art production technologies to fast track drug discovery. Our anti-CLU recombinant antibodies are generated in mammalian cell lines to ensure full glycosylation, which is critical for detection of the native, secreted form of this complex chaperone.

Featured Anti-CLU Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CLU recombinant antibody production.

Fig.4 Gram-scale anti-CLU recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to supporting the research community with flexible and innovative tools. Our anti-CLU recombinant antibodies are available in a variety of customizable modalities, including full-length IgGs for in vivo use and as matched pairs for diagnostic assay development.

Fig.5 Full-length anti-CLU recombinant antibody production and modalities.

CLU-Targeted Drug Information

Table 2. Public drug targeting CLU.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Accelerate your research with Creative Biolabs’ premier anti-Clusterin recombinant antibodies. Our antibody portfolio is built on principles of high specificity and functional validation to provide you with the best tools for your fundamental research and therapeutic development. We have the expertise to support your important work. Contact our specialists today.