Antibodies reactive against antigenic domain 4 (AD4) (amino acids 121-132 and 344-438) of CMV AD169 envelope glycoprotein B (gB) were isolated from the plasma of a healthy volunteer having CMV- neutralizing activity. The anti-human cytomegalovirus antibody (C11) has high affinity to CMV with KD value of 5.67 nM. It can be used in the research of treatment, prophylaxis, detection, and diagnosis of human cytomegalovirus infection.
Figure 1 Immunoblot analysis of proteins precipitated with different MAbs from an HCMV-infected HELF antigen extract using MAb 28-77 as the detecting antibody
Lane 1, proteins precipitated with Mab 9220; 2, proteins precipitated with MAb CMV-C10; 3, proteins precipitated with MAb CMV-C 11.
Grefte, J. M. M., Van der Gun, B. T. F., Schmolke, S., Van der Giessen, M., Van Son, W. J., Plachter, B., & Jahn, G. (1992). The lower matrix protein pp65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infection. Journal of General Virology, 73(11), 2923-2932.
Figure 2 Determination of the specificity of MAb CMV-C11 by transient transfection experiments using pp65-RSV and indirect immunofluorescence.
Determination of the specificity of MAb CMV-C11 by transient transfection experiments using pp65-RSV and indirect immunofluorescence.
Grefte, J. M. M., Van der Gun, B. T. F., Schmolke, S., Van der Giessen, M., Van Son, W. J., Plachter, B., & Jahn, G. (1992). The lower matrix protein pp65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infection. Journal of General Virology, 73(11), 2923-2932.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-2-sdAb | Recombinant Anti-CMV VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-041MZ-S(P) | Human Anti-CMV Recombinant Antibody; scFv Fragment (TAB-041MZ-S(P)) | FC | Human scFv |
TAB-042MZ-S(P) | Human Anti-CMV Recombinant Antibody; scFv Fragment (TAB-042MZ-S(P)) | FC | Human scFv |
TAB-043MZ-S(P) | Human Anti-CMV Recombinant Antibody; scFv Fragment (TAB-043MZ-S(P)) | FC | Human scFv |
TAB-044MZ-S(P) | Human Anti-CMV Recombinant Antibody; scFv Fragment (TAB-044MZ-S(P)) | FC | Human scFv |
TAB-045MZ-S(P) | Human Anti-CMV Recombinant Antibody; scFv Fragment (TAB-045MZ-S(P)) | FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1455CQ | Recombinant Mouse Anti-CMV Antibody (15B312) | IF | Mouse antibody |
MRO-1456CQ | Recombinant Mouse Anti-CMV Antibody (3H2047) | IHC | Mouse antibody |
MRO-1457CQ | Recombinant Mouse Anti-CMV Antibody (8B1.2, 1G5.2 and 2D4.2) | IHC-P, IHC-Fr | Mouse antibody |
HPAB-AP305-YC | Recombinant Human Anti-CMV Antibody (C4) | ELISA, Neut (< 0.04 µg/ml) | Human IgG |
HPAB-AP306-YC | Recombinant Human Anti-CMV Antibody (C5) | ELISA, Neut (< 6 µg/ml) | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-162 | Afuco™ Anti-CMV ADCC Recombinant Antibody (Sevirumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1083-FY-F(E) | Recombinant Anti-CMV Antibody scFv Fragment (H9) | ELISA, Cyt, FC | Human scFv |
HPAB-AP296-YC-S(P) | Recombinant Human Anti-CMV Antibody scFv Fragment (C1) | ELISA | Human scFv |
HPAB-AP297-YC-S(P) | Recombinant Human Anti-CMV Antibody scFv Fragment (C10) | ELISA | Human scFv |
FAMAB-0069WJ-S(P) | Human Anti-CMV Recombinant Antibody (clone 4D4); scFv Fragment | ELISA. IF | Human scFv |
FAMAB-0108WJ-S(P) | Human Anti-CMV Recombinant Antibody (clone HCV-65); scFv Fragment | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP296-YC-F(E) | Recombinant Human Anti-CMV Antibody Fab Fragment (C1) | ELISA | Human Fab |
HPAB-AP297-YC-F(E) | Recombinant Human Anti-CMV Antibody Fab Fragment (C10) | ELISA | Human Fab |
FAMAB-0105WJ-F(E) | Human Anti-CMV Recombinant Antibody (clone HCV-2); Fab Fragment | ELISA | Human Fab |
FAMAB-0106WJ-F(E) | Human Anti-CMV Recombinant Antibody (clone HCV-3); Fab Fragment | ELISA | Human Fab |
FAMAB-0107WJ-F(E) | Human Anti-CMV Recombinant Antibody (clone HCV-63); Fab Fragment | ELISA | Human Fab |
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