Anti-CRLF2 Antibody Prodrug, Protease Activated (VS-1025-YC41)
CAT#: VS-1025-YC41
The Anti-CRLF2 Antibody Prodrug, Protease Activated (VS-1025-YC41) is an antibody prodrug comprised of a recombinant human antibody targeting human CRLF2, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CRLF2 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CRLF2 effectively. CRLF2 (Cytokine Receptor-Like Factor 2) is a cytokine receptor whose overexpression due to gene translocation or rearrangement is a significant oncogenic driver in a subset of B-cell Acute Lymphoblastic Leukemia (B-ALL). This overexpression leads to the activation of the JAK/STAT signaling pathway, promoting uncontrolled proliferation and conferring a poor prognosis.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000205755-CRLF2
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human CRLF2
- Target
- CRLF2
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL.
- Alternative Names
- CRL2; TSLPR; CRLF2Y
- Gene ID
- 64109
- UniProt ID
- Q9HC73
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Datasheet
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COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201CQ | Human Anti-CRLF2 Recombinant Antibody (TAB-201CQ) | ELISA, Neut | Human IgG |
| TAB-204CQ | Anti-Human CRLF2 Recombinant Antibody (NV163-1) | ELISA, Inhib | Human antibody |
| TAB-205CQ | Anti-Human CRLF2 Recombinant Antibody (NV164-1) | ELISA, Inhib | Human antibody |
| TAB-201CQ-S(P) | Human Anti-CRLF2 Recombinant Antibody; scFv Fragment (TAB-201CQ-S(P)) | ELISA, Neut | Human scFv |
| TAB-204CQ-S(P) | Anti-Human CRLF2 Recombinant Antibody scFv Fragment (NV163-1) | ELISA, Inhib | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-202CQ | Anti-Human CRLF2 Recombinant Antibody (TSLPR-012) | Inhib | |
| TAB-206CQ | Mouse Anti-CRLF2 Recombinant Antibody (TAB-206CQ) | ELISA, FC, Neut | Mouse IgG1, κ |
| TAB-209CQ | Rat Anti-CRLF2 Recombinant Antibody (TAB-209CQ) | ELISA, FC, Neut | Rat IgG |
| TAB-210CQ | Mouse Anti-CRLF2 Recombinant Antibody (TAB-210CQ) | ELISA, FC, Neut | Mouse IgG1, κ |
| TAB-211CQ | Mouse Anti-CRLF2 Recombinant Antibody (TAB-211CQ) | ELISA, FC, Neut | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-203CQ | Anti-Human CRLF2 Recombinant Antibody (TSLPR-012-141) | ELISA, FC, Inhib | Humanized antibody |
| TAB-208CQ | Human Anti-CRLF2 Recombinant Antibody (TAB-208CQ) | ELISA, FC, Neut | Humanized IgG1, κ |
| TAB-203CQ-S(P) | Anti-Human CRLF2 Recombinant Antibody scFv Fragment (TSLPR-012-141) | ELISA, FC, Inhib | Humanized antibody |
| TAB-208CQ-S(P) | Human Anti-CRLF2 Recombinant Antibody; scFv Fragment (TAB-208CQ-S(P)) | ELISA, FC, Neut | Humanized scFv |
| TAB-203CQ-F(E) | Anti-Human CRLF2 Recombinant Antibody Fab Fragment (TSLPR-012-141) | ELISA, FC, Inhib | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-207CQ | Human Anti-CRLF2 Recombinant Antibody (TAB-207CQ) | ELISA, FC, Neut | Chimeric (mouse/human) IgG1, κ |
| TAB-207CQ-S(P) | Mouse Anti-CRLF2 Recombinant Antibody; scFv Fragment (TAB-207CQ-S(P)) | ELISA, FC, Neut | Mouse scFv |
| TAB-207CQ-F(E) | Human Anti-CRLF2 Recombinant Antibody; Fab Fragment (TAB-207CQ-F(E)) | ELISA, FC, Neut | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1999MZ | Recombinant Mouse Anti-Human CRLF2 Antibody | ICC, IF, WB | Mouse antibody |
| HPAB-0216-WJ | Human Anti-CRLF2 Recombinant Antibody (HPAB-0216-WJ) | ELISA, FC | Humanized IgG |
| HPAB-0268-YJ | Mouse Anti-CRLF2 Recombinant Antibody (clone 1D6 (1D6.C9)) | Antagonist, ELISA, FC, Inhib | Mouse IgG1 |
| HPAB-0269-YJ | Human Anti-CRLF2 Recombinant Antibody (clone 1D6 (1D6.C9)) | Antagonist, ELISA, FC, Inhib | Chimeric (mouse/human) IgG1 |
| HPAB-1085-FY | Mouse Anti-CRLF2 Recombinant Antibody (HPAB-1085-FY) | IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0216-WJ-S(P) | Human Anti-CRLF2 Recombinant Antibody; scFv Fragment (HPAB-0216-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0268-YJ-S(P) | Mouse Anti-CRLF2 Recombinant Antibody (clone 1D6 (1D6.C9)); scFv Fragment | Antagonist, ELISA, FC, Inhib | Mouse scFv |
| HPAB-1085-FY-F(E) | Mouse Anti-CRLF2 Recombinant Antibody; Fab Fragment (HPAB-1085-FY-F(E)) | Neut | Mouse Fab |
| HPAB-1086-FY-F(E) | Mouse Anti-CRLF2 Recombinant Antibody; Fab Fragment (HPAB-1086-FY-F(E)) | Neut | Mouse Fab |
| HPAB-1087-FY-F(E) | Mouse Anti-CRLF2 Recombinant Antibody; Fab Fragment (HPAB-1087-FY-F(E)) | Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0216-WJ-F(E) | Human Anti-CRLF2 Recombinant Antibody; Fab Fragment (HPAB-0216-WJ-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0268-YJ-F(E) | Mouse Anti-CRLF2 Recombinant Antibody (clone 1D6 (1D6.C9)); Fab Fragment | Antagonist, ELISA, FC, Inhib | Mouse Fab |
| HPAB-0269-YJ-F(E) | Human Anti-CRLF2 Recombinant Antibody (clone 1D6 (1D6.C9)); Fab Fragment | Antagonist, ELISA, FC, Inhib | Human Fab |
| HPAB-1085-FY-S(P) | Mouse Anti-CRLF2 Recombinant Antibody; scFv Fragment (HPAB-1085-FY-S(P)) | Neut | Mouse scFv |
| HPAB-1086-FY-S(P) | Mouse Anti-CRLF2 Recombinant Antibody; scFv Fragment (HPAB-1086-FY-S(P)) | Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY50 | Hamster Anti-CRLF2 (clone TSLPR-012) scFv-Fc Chimera | Inhib, ELISA, FC | Hamster IgG, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC528 | Recombinant Anti-CRLF2 Vesicular Antibody, EV Displayed (VS-0425-YC528) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1677 | Anti-CRLF2 Immunohistochemistry Kit | IHC |
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