Hamster Anti-CRLF2 (clone TSLPR-012) scFv-Fc Chimera (CAT#: VS-0425-FY50)
The anti-CRLF2 scFv-Fc fusion protein is an engineered therapeutic aimed at targeting Cytokine Receptor-Like Factor 2 (CRLF2), a protein implicated in certain hematological malignancies. This fusion construct combines a single-chain variable fragment (scFv) designed for high-specificity binding to CRLF2 with an Fc domain to enhance stability and prolong its in-vivo half-life. By selectively binding to CRLF2, the protein intends to disrupt CRLF2-mediated signaling pathways, which contribute to the proliferation of malignant cells. This disruption may have potential therapeutic benefits in specific forms of leukemia. The presence of the Fc region within the protien increases the proteins duration in the patients system. Ongoing studies are being conducted to investigate it's effectivness in clinical trails.
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RNA Expression
Figure 1 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000205755-CRLF2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000205755-CRLF2
Specifications
- Immunogen
- Recombinant human soluble TSLPR-Fc fusion protein as an immunogen.
- Host Species
- Hamster
- Type
- Hamster IgG, scFv-Fc
- Specificity
- Human CRLF2
- Species Reactivity
- Human, Cynomolgus monkey
- Clone
- TSLPR-012
- Applications
- Inhibition, ELISA, Flow Cytometry
- Related Disease
- Asthma, atopic dermatitis or rheumatoid arthritis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Cytokine Receptor Like Factor 2; Thymic Stromal Lymphopoietin Protein Receptor; TSLP Receptor; IL-XR; TSLPR; CRL2; Thymic Stromal-Derived Lymphopoietin Receptor
- Gene ID
- 64109
- UniProt ID
- Q9HC73
- Long Name
- Cytokine Receptor Like Factor 2
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 5 subfamily.
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- Glycosylation at Asn47, Asn55, Asn169, and Asn101
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites, 1 N-linked glycan (1 site)
- Protein Refseq
- XP_011543936.1; XP_011544483.1; XP_054183545.1; XP_054184294.1; NP_001012288.2
- Function
- Receptor for thymic stromal lymphopoietin (TSLP).
Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5.
Also activates JAK2.
Implicated in the development of the hematopoietic system.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201CQ | Human Anti-CRLF2 Recombinant Antibody (TAB-201CQ) | ELISA, Neut | Human IgG |
| TAB-204CQ | Anti-Human CRLF2 Recombinant Antibody (NV163-1) | ELISA, Inhib | Human antibody |
| TAB-205CQ | Anti-Human CRLF2 Recombinant Antibody (NV164-1) | ELISA, Inhib | Human antibody |
| TAB-201CQ-F(E) | Human Anti-CRLF2 Recombinant Antibody; Fab Fragment (TAB-201CQ-F(E)) | ELISA, Neut | Human Fab |
| TAB-204CQ-F(E) | Anti-Human CRLF2 Recombinant Antibody Fab Fragment (NV163-1) | ELISA, Inhib | Human antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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