Rabbit Anti-CUL4B Recombinant Antibody (clone R06-3D3) (CAT#: VS3-FY1689)
This is a rabbit recombinant monoclonal antibody that is involved in the recognition of human CUL4B. It cross-reacts with hamster, rat. The R06-3D3 is recommended for dilution with western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/58979/995_G5_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/58979/995_G5_2_selected.jpg
Figure 2 Epididymis
(High expression in epididymis)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11880/29380_A_2_6_val_selected.jpg
(High expression in epididymis)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11880/29380_A_2_6_val_selected.jpg
Figure 3 IHC staining of human esophagus
(Immunohistochemical staining of human esophagus shows nuclear positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17786/ihc_selected.jpg
(Immunohistochemical staining of human esophagus shows nuclear positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17786/ihc_selected.jpg
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11880/29380_A_7_3.jpg
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11880/29380_A_7_3.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000158290-CUL4B
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000158290-CUL4B
Specifications
- Immunogen
- Synthetic peptide of human Cullin 4B
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Hamster, Rat CUL4B
- Species Reactivity
- Human, Hamster, Rat
- Clone
- R06-3D3
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- MW
- The calculated weight of the target protein is approximately 104 kDa, while the observed molecular weight stands at 88,104 kDa.
- Related Disease
- Mental Retardation, X-Linked, Syndromic, Cabezas Type and Seizure Disorder
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Cullin 4B; CUL-4B; Cullin-4B; KIAA0695; MRXHF2; MRXS15; MRXSC; SFM2
- Gene ID
- 8450
- UniProt ID
- Q13620
- Sequence Similarities
- Belongs to the cullin family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
- Protein Refseq
- NP_001073341.1; NP_001317553.1; NP_001356074.1; NP_003579.3
- Function
- CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CUL4B"
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0877 | Hi-Affi™ Rabbit Anti-CUL4B Recombinant Antibody (clone DS877AB) | WB, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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