Recombinant Anti-CYCS (AA 44-47 x AA 60-62) Biparatopic Antibody, Tandem scFv (Clone 2F8.C10 x Clone 6A7.E5)
CAT#: VS-0525-YC42
The recombinant Anti-CYCS (AA 44-47 x AA 60-62) biparatopic antibody, tandem scFv (Clone 2F8.C10 x Clone 6A7.E5), targets two distinct regions on rat cytochrome c. It is designed as a tandem scFv, linking the 2F8.C10 scFv, which targets amino acids 44-47, with the 6A7.E5 scFv, which targets amino acids 60-62, fused at the N-terminus.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human heart muscle
Immunohistochemical staining of human heart muscle shows moderate cytoplasmic positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18597/42408_B_6_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12177_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Bowman's capsule
Staining: High
Intensity: Strong
Quantity:>75%
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining: High
Intensity: Strong
Quantity:>75%
Proximal tubules (cell body)
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: Medium
Intensity: Strong
Quantity: <25%
Round or early spermatids
Staining: Medium
Intensity: Strong
Quantity: <25%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_6_6.jpg
Normal Tissue
Figure 8 Heart muscle
Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12177_B_5_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172115-CYCS
❮
❯
Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Mouse
- Specificity
- Rat cytochrome c
- Species Reactivity
- Rat
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- 2F8.C10
- Clone 2
- 6A7.E5
- Epitope 1
- aa 44-47 of rat cytochrome c
- Epitope 2
- aa 60-62 of rat cytochrome c
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Cytochrome C, Somatic
Target
- Introduction
- This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.
- Alternative Names
- CYCSA; Cycs; Cytochrome c
- Gene ID
- 25309
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Datasheet
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COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY1840 | Anti-Canine CYCS Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC40 | Recombinant Anti-CYCS (AA 44-47 x AA 60-62) Biparatopic Antibody, Tandem scFv (Clone 1G1.E9 x Clone 1F5.D1) | ELISA | Tandem scFv |
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