Rabbit Anti-DAB2 Recombinant Antibody (VS13-YC285) (CAT#: VS13-YC285)
The Rabbit Anti-DAB2 Recombinant Antibody is specific for human DAB2. DAB2 encodes a phosphoprotein expressed in normal ovarian cells but often down-regulated in carcinoma, suggesting tumor suppressor roles with interactions in growth factor pathways via proteins like GRB2. The anti-DAB2 antibody can be used for Western blot (1/500-1/1000), Immunohistochemistry (1/50-1/100), Immunoprecipitation (1/20).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nucleoli fibrillar center, plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28888/785_H11_7_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nucleoli fibrillar center, plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28888/785_H11_7_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9314/996_D1_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9314/996_D1_1_selected.jpg
Figure 3 Placenta
(Decidual cells Staining: Low Intensity: Weak Quantity:>75% Hofbauer cells Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - cell body Staining: Medium Intensity: Moderate Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28888/134186_A_1_7.jpg
(Decidual cells Staining: Low Intensity: Weak Quantity:>75% Hofbauer cells Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - cell body Staining: Medium Intensity: Moderate Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28888/134186_A_1_7.jpg
Figure 4 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, TIME, U-138 MG)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000153071-DAB2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000153071-DAB2
Specifications
- Immunogen
- Recombinant human DAB2.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human DAB2
- Species Reactivity
- Human
- Applications
- WB, IHC-P, IP
- Conjugate
- NONE
- Related Disease
- Teratocarcinoma and Hypercholesterolemia, Familial
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Immunoprecipitation (IP): 1/20
Target
- Alternative Names
- DAB2, Clathrin Adaptor Protein; Differentially Expressed In Ovarian Carcinoma 2; Differentially-Expressed Protein 2; Adaptor Molecule Disabled-2; DOC-2; DOC2; Disabled (Drosophila) Homolog 2 (Mitogen-Responsive Phosphoprotein);
- Gene ID
- 1601
- UniProt ID
- P98082
- Long Name
- DAB2, Clathrin Adaptor Protein
- Cellular Localization
- Coated pit; Cytoplasm; Cytoplasmic vesicle; Membrane
- Protein Refseq
- NP_001231800.1; NP_001334.2
- Function
- Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0918 | Hi-Affi™ Rabbit Anti-DAB2 Recombinant Antibody (clone DS918AB) | WB | Rabbit IgG |
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