Rabbit Anti-DAB2 Recombinant Antibody (clone R04-2A1) (CAT#: VS3-FY1994)

• Immunogen
• Synthetic peptide of human DAB2

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat DAB2

• Species Reactivity
• Human, Rat

• Clone
• R04-2A1

• Applications
• Western Blot, Immunofluorescence, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 82 kDa, while the observed molecular weight stands at 96 kDa.

• Related Disease
• Teratocarcinoma and Hypercholesterolemia, Familial, 4

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunofluorescence: 1/50-1/200
  Immunoprecipitation: 1/20

• Alternative Names
• DAB2, Clathrin Adaptor Protein; Differentially Expressed In Ovarian Carcinoma 2; Differentially-Expressed Protein 2; Adaptor Molecule Disabled-2; DOC-2; DOC2; Disabled (Drosophila) Homolog 2 (Mitogen-Responsive Phosphoprotein)

• Gene ID
• 1601

• UniProt ID
• P98082

• Cellular Localization
• Coated pit, Cytoplasm, Cytoplasmic vesicle, Membrane

• Post Translation Modifications
• Phosphorylated.
  Phosphorylation during mitosis is leading to membrane displacement ().
  (P98082-DAB2_HUMAN)
  Modification sites at PhosphoSitePlus (P98082)
  Modification sites at neXtProt (NX_P98082)
  Glycosylation from GlyGen (P98082) 13 sites, 1 O-linked glycan (13 sites)

• Protein Refseq
• NP_001231800.1; NP_001334.2

• Function
• Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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