Anti-DDR2 Antibody Prodrug, Protease Activated (VS-1025-YC45)
CAT#: VS-1025-YC45
The Anti-DDR2 Antibody Prodrug, Protease Activated (VS-1025-YC45) is an antibody prodrug comprised of a recombinant human antibody targeting human DDR2, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to DDR2 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to DDR2 effectively. DDR2 (Discoidin Domain Receptor 2) is a unique receptor tyrosine kinase activated by binding to collagen in the extracellular matrix. Activating mutations in DDR2 are found in a subset of squamous cell lung carcinomas (SqCLC), leading to constitutive kinase activity. This dysregulation is a targetable oncogenic driver, for which specific tyrosine kinase inhibitors are being investigated.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to actin filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70112/1658_F6_3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, fHDF/TERT166, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000162733-DDR2
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human DDR2
- Target
- DDR2
- Species Reactivity
- Human
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This is an antibody that specifically binds to an extracellular domain of human DDR2 and has a therapeutic effect on the solid tumor and cancer.
- Alternative Names
- DDR2; discoidin domain receptor tyrosine kinase 2; TKT; MIG20a; NTRKR3; TYRO10
- Gene ID
- 4921
- UniProt ID
- A0A024R906
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "DDR2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-186MZ | Mouse Anti-DDR2 Recombinant Antibody (TAB-186MZ) | FuncS | Mouse IgG |
| TAB-185MZ-S(P) | Mouse Anti-DDR2 Recombinant Antibody; scFv Fragment (TAB-185MZ-S(P)) | ELISA | Mouse scFv |
| TAB-186MZ-S(P) | Mouse Anti-DDR2 Recombinant Antibody; scFv Fragment (TAB-186MZ-S(P)) | ELISA | Mouse scFv |
| TAB-185MZ-F(E) | Mouse Anti-DDR2 Recombinant Antibody; Fab Fragment (TAB-185MZ-F(E)) | ELISA | Mouse Fab |
| TAB-186MZ-F(E) | Mouse Anti-DDR2 Recombinant Antibody; Fab Fragment (TAB-186MZ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1359MZ | Recombinant Mouse Anti-Human DDR2 Antibody (clone 4C22F5) | ELISA, ICC, IF, IHC-P, WB | Mouse antibody |
| ZG-0476F | Mouse Anti-DDR2 Recombinant Antibody (ZG-0476F) | WB, IHC, IF, ELISA | Mouse IgG |
| VS3-QX321 | Mouse Anti-DDR2 Recombinant Antibody (clone 484CT5.5.4) | WB | Mouse IgG1 |
| VS3-XY572 | Mouse Anti-DDR2 Recombinant Antibody (clone 3B11E4) | ELISA, WB, IHC, ICC | Mouse IgG2a |
| VS7-HM811 | Mouse Anti-DDR2 Recombinant Antibody (clone CBL193HM) | WB, IHC-p, IF, ICC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0954 | Hi-Affi™ Rabbit Anti-DDR2 Recombinant Antibody (clone DS954AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY639 | Anti-DDR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1946 | Anti-Mouse DDR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1945 | Anti-Human DDR2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC220 | Recombinant Anti-DDR2 Vesicular Antibody, EV Displayed (VS-0425-YC220) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC98 | SmartAb™ Recombinant Anti-DDR2 pH-dependent Antibody (VS-0825-YC98) | ELISA | Mouse IgG |
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