SmartAb™ Recombinant Anti-DDR2 pH-dependent Antibody (VS-0825-YC98)
CAT#: VS-0825-YC98
The anti-DDR2 pH-dependent antibody (VS-0825-YC98) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to human DDR2. By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for DDR2 under acidic conditions compared to physiological pH. Using a yeast surface display system with pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from DDR2 at pH 6.0. This pH-sensitive antibody retains its binding affinity for DDR2 on tumor cells while exhibiting negligible binding to the receptor on normal cells at physiological pH. Human DDR2, or Discoidin Domain Receptor 2, is a receptor tyrosine kinase that binds to collagen. It is involved in cell-matrix interactions and is a key player in the development of fibrotic diseases and in the progression of certain cancers.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to actin filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70112/1658_F6_3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, fHDF/TERT166, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000162733-DDR2
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Specifications
- Immunogen
- Recombinant human DDR2 protein.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human DDR2
- Species Reactivity
- Human
- Applications
- ELISA
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
- Alternative Names
- DDR2; discoidin domain receptor tyrosine kinase 2; TKT; MIG20a; NTRKR3; TYRO10; discoidin domain-containing receptor 2; tyrosylprotein kinase; hydroxyaryl-protein kinase; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; cell migration-inducing protein 20; migration-inducing gene 16 protein; receptor protein-tyrosine kinase TKT; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; discoidin domain-containing receptor tyrosine kinase 2
- Gene ID
- 4921
- UniProt ID
- A0A024R906
- Long Name
- Discoidin Domain Receptor Tyrosine Kinase 2
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "DDR2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-186MZ | Mouse Anti-DDR2 Recombinant Antibody (TAB-186MZ) | FuncS | Mouse IgG |
| TAB-185MZ-S(P) | Mouse Anti-DDR2 Recombinant Antibody; scFv Fragment (TAB-185MZ-S(P)) | ELISA | Mouse scFv |
| TAB-186MZ-S(P) | Mouse Anti-DDR2 Recombinant Antibody; scFv Fragment (TAB-186MZ-S(P)) | ELISA | Mouse scFv |
| TAB-185MZ-F(E) | Mouse Anti-DDR2 Recombinant Antibody; Fab Fragment (TAB-185MZ-F(E)) | ELISA | Mouse Fab |
| TAB-186MZ-F(E) | Mouse Anti-DDR2 Recombinant Antibody; Fab Fragment (TAB-186MZ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1359MZ | Recombinant Mouse Anti-Human DDR2 Antibody (clone 4C22F5) | ELISA, ICC, IF, IHC-P, WB | Mouse antibody |
| ZG-0476F | Mouse Anti-DDR2 Recombinant Antibody (ZG-0476F) | WB, IHC, IF, ELISA | Mouse IgG |
| VS3-QX321 | Mouse Anti-DDR2 Recombinant Antibody (clone 484CT5.5.4) | WB | Mouse IgG1 |
| VS3-XY572 | Mouse Anti-DDR2 Recombinant Antibody (clone 3B11E4) | ELISA, WB, IHC, ICC | Mouse IgG2a |
| VS7-HM811 | Mouse Anti-DDR2 Recombinant Antibody (clone CBL193HM) | WB, IHC-p, IF, ICC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0954 | Hi-Affi™ Rabbit Anti-DDR2 Recombinant Antibody (clone DS954AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY639 | Anti-DDR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1946 | Anti-Mouse DDR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1945 | Anti-Human DDR2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC220 | Recombinant Anti-DDR2 Vesicular Antibody, EV Displayed (VS-0425-YC220) | ELISA, FC, Cell-uptake |
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