Recombinant Anti-DDR2 Vesicular Antibody, EV Displayed (VS-0425-YC220)
CAT#: VS-0425-YC220
The Recombinant Anti-DDR2 Vesicular Antibody, EV Displayed (VS-0425-YC220) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to DDR2-expressed cells or tissues. The DDR2 is a receptor tyrosine kinase, collagen-induced, affecting cell adhesion and proliferation. It is implicated in wound repair and tumor growth. Mutations cause spondylometaepiphyseal dysplasia.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to actin filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70112/1658_F6_3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, fHDF/TERT166, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000162733-DDR2
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- DDR2
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Discoidin domain receptor tyrosine kinase 2
- Biological Process
- Osteogenesis
- Molecular Function
- Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Plasma membrane, Actin filaments
- Introduction
- This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia.
- Alternative Names
- NTRKR3, TKT, TYRO10
- Gene ID
- 4921
- UniProt ID
- Q16832
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Datasheet
MSDS
COA
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| TAB-186MZ-F(E) | Mouse Anti-DDR2 Recombinant Antibody; Fab Fragment (TAB-186MZ-F(E)) | ELISA | Mouse Fab |
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