Human Anti-dsDNA Recombinant Antibody (clone DIL-6) (CAT#: FAMAB-0014WJ)
This product is an IgG3, λ antibody with restricted antigen binding specificity.
Specific Inquiry
ELISA
Figure 1 Binding of mAb RH-14 and DIL-6 to dsDNA attached to immunoassay plates was inhibited by dsDNA in the fluid phase.
Analyzed by competitive inhibition ELISA.
Ravirajan, C. T., Rahman, M. A., Papadaki, L., Griffiths, M. H., Kalsi, J., Martin, A. C., ... & Isenberg, D. A. (1998). Genetic, structural and functional properties of an IgG DNA‐binding monoclonal antibody from a lupus patient with nephritis. European journal of immunology, 28(1), 339-350.
ELISA
Figure 2 Binding of human anti-DNA IgG antibodies (Hu IgG) to α-actinin.
The pathogenic antibodies RH14 and B3 bound strongly to α-actinin, while the nonpathogenic antibody DIL-6 showed very weak binding to -actinin. Anti– -actinin binding was measured by solidphase enzyme-linked immunosorbent assay.
Ravirajan, C. T., Rahman, M. A., Papadaki, L., Griffiths, M. H., Kalsi, J., Martin, A. C., ... & Isenberg, D. A. (1998). Genetic, structural and functional properties of an IgG DNA‐binding monoclonal antibody from a lupus patient with nephritis. European journal of immunology, 28(1), 339-350.
Specifications
- Host Species
- Human
- Type
- Human IgG3, λ
- Specificity
- dsDNA
- Clone
- DIL-6
- Applications
- ELISA
- Related Disease
- Systemic lupus erythematosus
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The dsDNA antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- Double-stranded DNA; dsDNA
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-077 | Mouse Anti-dsDNA Recombinant Antibody (clone 64M-5); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
| FAMAB-0013WJ-S(P) | Human Anti-dsDNA Recombinant Antibody (clone RH-14); scFv Fragment | ELISA | Human scFv |
| FAMAB-0047WJ-S(P) | Human Anti-dsDNA Recombinant Antibody (clone T14); scFv Fragment | WB | Human scFv |
| FAMAB-0058JF-S(P) | Human Anti-dsDNA Recombinant Antibody (clone A6); scFv Fragment | FC, WB, IHC, ELISA, FuncS | Human scFv |
| FAMAB-0151JF-S(P) | Mouse Anti-dsDNA Recombinant Antibody (clone G6-7); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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