Mouse Anti-DTX2 Recombinant Antibody (VS-0326-YC1178)
CAT#: VS-0326-YC1178
This product is an anti-DTX2 antibody panel that contains two antibodies targeting human DTX2. DTX2 is an E3 ubiquitin ligase that acts as a regulator of the Notch signaling pathway. It contains a RING finger domain and facilitates the ubiquitination of the Notch intracellular domain (NICD). DTX2-mediated signaling can modulate Notch-dependent cell fate decisions and has been implicated in the cellular response to DNA damage and repair. Two monoclonal antibodies, VS-0326-YC782 and VS-0326-YC783, directed against DTX2 were used for in vitro assays including Immunohistochemistry (IHC) and Immunoprecipitation (IP).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & nuclear membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42931/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human esophagus
Immunohistochemical staining of human esophagus shows cytoplasmic and nuclear positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42931/99105_B_4_1_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42931/99105_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42931/99105_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42931/99105_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42931/99105_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42931/99105_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (A549, CAPAN-2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091073-DTX2
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| Sub Cat | Type | Clone | Species Reactivity | Applications | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS-0326-YC782 | Mouse IgG2a | DT782 | Human | IHC | IHC (1/100-1/200) | ||||||
| VS-0326-YC783 | Mouse IgG1 | DT783 | Human | IP | IP (1/100-1/200) |
More Infomation
Specifications
- Host Species
- Mouse
- Specificity
- Human DTX2
- Conjugate
- The unconjugated, Biotin and FITC formats are available.
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Target
- Alternative Names
- Deltex E3 Ubiquitin Ligase 2; RING-Type E3 Ubiquitin Transferase DTX2; Deltex 2, E3 Ubiquitin Ligase; Protein Deltex-2; Deltex2; RNF58; HDTX2; Probable E3 Ubiquitin-Protein Ligase DTX2; Deltex (Drosophila) Homolog 2;
- Gene ID
- 113878
- UniProt ID
- Q86UW9
- Long Name
- Deltex E3 Ubiquitin Ligase 2
- Post Translation Modifications
- Unmodified
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "DTX2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1059 | Hi-Affi™ Rabbit Anti-DTX2 Recombinant Antibody (clone DS1059AB) | FC, IP, IHC-P, WB | Rabbit IgG |
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