Rabbit Anti-DYNLT1 Recombinant Antibody (clone R03-6F2) (CAT#: VS3-FY2091)

• Immunogen
• Recombinant human TCTEX-1 protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat DYNLT1

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R03-6F2

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 12 kDa, while the observed molecular weight stands at 12 kDa.

• Related Disease
• Glaucomatocyclitic Crisis and Pulmonary Hypertension

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200
  Immunoprecipitation: 1/20

• Alternative Names
• Dynein Light Chain Tctex-Type 1; T-Complex-Associated-Testis-Expressed 1-Like 1; T-Complex Testis-Specific Protein 1 Homolog; Tctex-1; TCTEL1; Protein CW-1; TCTEX1; CW-1

• Gene ID
• 6993

• UniProt ID
• P63172

• Sequence Similarities
• Belongs to the dynein light chain Tctex-type family.

• Cellular Localization
• Cytoplasm, Cytoskeleton, Dynein, Golgi apparatus, Microtubule

• Post Translation Modifications
• Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIM:178600].
  The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release ().
  (P63172-DYLT1_HUMAN)
  Ubiquitination at Lys56 (NX_P63172 [NX_P63172-1])
  Modification sites at PhosphoSitePlus (P63172)
  Glycosylation from GlyGen (P63172) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_001278531.1; NP_001278532.1; NP_006510.1

• Function
• Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

Select a product category from the dropdown menu below to view related products.