Mouse Anti-ERBIN Recombinant Antibody (VS3-FY2932)
CAT#: VS3-FY2932
The anti-ERBIN antibody is a mouse recombinant monoclonal antibody that is specifically created to bind human, mouse, rat ERBIN protein, a calculated molecular weight of the protein is about 158.3 kDa. This monoclonal antibody proves valuable in disease research related to Petrous Apex Meningioma and Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia. The antibody can be utilized for detection of ERBIN by Western Blot (1/500-1/1000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear speckles, plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59863/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human breast
Immunohistochemical staining of human breast shows strong cytoplasmic positivity in myoepithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_7_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_7_5.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112851-ERBIN
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse and Rat ERBIN
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 158.3 kDa.
- Related Disease
- Petrous Apex Meningioma and Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Erbb2 Interacting Protein; Densin-180-Like Protein; ERBB2-Interacting Protein; Protein LAP2; ERBB2IP; LAP2
- Gene ID
- 55914
- UniProt ID
- Q96RT1
- Sequence Similarities
- Belongs to the LAP (LRR and PDZ) protein family.
- Cellular Localization
- Cell junction, hemidesmosome
Nucleus membrane
Basolateral cell membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q96RT1)
Modification sites at neXtProt (NX_Q96RT1)
Glycosylation from GlyGen (Q96RT1) 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_047273332.1; XP_047273333.1; XP_047273334.1; XP_047273335.1
- Function
- Acts as an adapter for the receptor ERBB2, in epithelia.
By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728).
Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "ERBIN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1110 | Mouse Anti-ERBIN Recombinant Antibody (VS3-WK1110) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY780 | Anti-ERBIN Immunohistochemistry Kit | IHC |
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