Mouse Anti-ERBIN Recombinant Antibody (VS3-FY2932) (CAT#: VS3-FY2932)
The anti-ERBIN antibody is a mouse recombinant monoclonal antibody that is specifically created to bind human, mouse, rat ERBIN protein, a calculated molecular weight of the protein is about 158.3 kDa. This monoclonal antibody proves valuable in disease research related to Petrous Apex Meningioma and Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia. The antibody can be utilized for detection of ERBIN by Western Blot (1/500-1/1000).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/if_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear speckles, plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59863/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear speckles, plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59863/if_selected.jpg
Figure 3 IHC staining of human breast
(Immunohistochemical staining of human breast shows strong cytoplasmic positivity in myoepithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/ihc_selected.jpg
(Immunohistochemical staining of human breast shows strong cytoplasmic positivity in myoepithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/ihc_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_B_8_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_B_8_5.jpg
Figure 5 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_7_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_7_3.jpg
Figure 6 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_9_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_9_4.jpg
Figure 7 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_7_5.jpg
Figure 8 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_7_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48606/115415_A_7_8.jpg
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112851-ERBIN
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112851-ERBIN
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse and Rat ERBIN
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 158.3 kDa.
- Related Disease
- Petrous Apex Meningioma and Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Erbb2 Interacting Protein; Densin-180-Like Protein; ERBB2-Interacting Protein; Protein LAP2; ERBB2IP; LAP2
- Gene ID
- 55914
- UniProt ID
- Q96RT1
- Sequence Similarities
- Belongs to the LAP (LRR and PDZ) protein family.
- Cellular Localization
- Cell junction, hemidesmosome
Nucleus membrane
Basolateral cell membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q96RT1)
Modification sites at neXtProt (NX_Q96RT1)
Glycosylation from GlyGen (Q96RT1) 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_047273332.1; XP_047273333.1; XP_047273334.1; XP_047273335.1
- Function
- Acts as an adapter for the receptor ERBB2, in epithelia.
By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728).
Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1110 | Mouse Anti-ERBIN Recombinant Antibody (VS3-WK1110) | WB | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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