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Rabbit Anti-ESRRA Recombinant Antibody (VS3-CJ596) (CAT#: VS3-CJ596)

This product is a rabbit antibody that recognizes human, mouse, and rat ESRRA.


See more Engineered Antibody products for ESRRA
Specific Inquiry
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  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, nucleoli fibrillar center, microtubules & cytokinetic bridge.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53785/840_F4_2_selected.jpg
Figure 2 IHC staining of human small intestine
Figure 2 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77297/168442_A_5_2_selected.jpg
Figure 3 IF staining of human cell line PC-3
Figure 3 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm, nucleoli fibrillar center, microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53785/986_C3_1_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nucleoli fibrillar center, microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53785/832_C3_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77297/168442_B_8_5.jpg
Figure 6 Colon
Figure 6 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77297/168442_A_7_3.jpg
Figure 7 Kidney
Figure 7 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77297/168442_A_9_5.jpg
Figure 8 Testis
Figure 8 Testis
(Cells in seminiferous ducts
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77297/168442_A_5_6.jpg
Figure 9 Tonsil
Figure 9 Tonsil
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77297/168442_A_4_8.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Figure 10 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000173153-ESRRA

Specifications

  • Immunogen
  • Recombinant protein
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse, Rat ESRRA
  • Species Reactivity
  • Human, Mouse, Rat
  • Applications
  • WB, IP, FC
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Protein A affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 40% Glycerol, 1% BSA, TBS, pH7.4.
  • Preservative
  • 0.05% Sodium Azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Western Blot, Immunoprecipitation, Flow Cytometry.

Target

  • Alternative Names
  • ERR1; ERRa; ESRL1; NR3B1; ERRalpha
  • Sequence Similarities
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
  • Cellular Localization
  • Cytoplasm, Nucleus
  • Post Translation Modifications
  • Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
    Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding.
    Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
  • Function
  • Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

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Isotype Control

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "ESRRA"

Fab Fragment Antibody

CAT Product Name Application Type
DrMAB-319 Human Anti-ESRRA Recombinant Antibody (clone D42); Fab Fragment IP, IF, ELISA Human Fab

Recombinant Antibody

CAT Product Name Application Type
MOB-2366MZ Recombinant Mouse Anti-Human ESRRA Antibody (clone I6955) ELISA, IHC-P, IP, WB Mouse antibody
MRO-0556-CN Rabbit Anti-ESRRA Recombinant Antibody (clone CBACN-221) WB, IP, FC Rabbit IgG
MRO-1851-CN Rabbit Anti-ESRRA Polyclonal Antibody (MRO-1851-CN) WB, FC Rabbit IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1203 Hi-Affi™ Rabbit Anti-ESRRA Recombinant Antibody (clone DS1203AB) WB, IP, FC Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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