AibGenesis™ Rabbit Anti-FEN1 Recombinant Antibody (AibG-Rb-FE414)
CAT#: VS-0426-FY414
Developed through our AI-powered antibody discovery platform, this Rabbit IgG targets FEN1. Validated for WB and IHC in Human, Mouse, and Rat, it is an ideal reagent for investigating flap endonuclease activity during DNA replication, long-patch base excision repair, and genome stability maintenance.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2262/710_G8_4_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression in tonsil
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6748/18132_A_4_8_val_selected.jpg
Normal Tissue
Figure 3 Testis
Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2262/5862_A_5_6.jpg
Normal Tissue
Figure 4 Vagina
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2262/5862_B_3_2.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2262/5862_A_8_8.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2262/5862_A_9_4.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168496-FEN1
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human FEN1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-FE414
- Applications
- Western Blot, Immunohistochemistry
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Werner Syndrome; Xeroderma Pigmentosum, Variant Type
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, 0.05% Protective protein, 50% Glycerol
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:1000-1:2000), Immunohistochemistry (1:100-1:200)
Target
- Alternative Names
- DNase IV; FEN1; Flap endonuclease 1; Flap structure specific endonuclease 1; hFEN-1; hFEN1; Maturation factor 1; MF1; Rad2; FEN1
- UniProt ID
- P39748
- Long Name
- Flap Structure-Specific Endonuclease 1
- Cellular Localization
- Nucleus, nucleoplasm
- Post Translation Modifications
- Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA. (P39748-FEN1_HUMAN)
Ubiquitination at Lys8, Lys171, Lys254, and Lys345 (NX_P39748 [NX_P39748-1])
Modification sites at PhosphoSitePlus (P39748)
Glycosylation from GlyGen (P39748) 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- NP_004102.1
- Function
- Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.
Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.
Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "FEN1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3428z | Mouse Anti-FEN1 Recombinant Antibody (clone 19G12) | WB, ICC, IF, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0734CT | Recombinant Mouse anti-Human FEN1 Monoclonal antibody (5F8) | FC, ICC, IF, IHC-P, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1282 | Hi-Affi™ Rabbit Anti-FEN1 Recombinant Antibody (clone DS1282AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1145CQ | Mouse Anti-FEN1 Recombinant Antibody (clone SAIC-21C-4) | Immuno-MRM, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0337J | Mouse Anti-FEN1 Recombinant Antibody (ZG-0337J) | WB, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0338J | Mouse Anti-FEN1 Recombinant Antibody (ZG-0338J) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY828 | Anti-FEN1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2499 | Anti-Mouse FEN1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2498 | Anti-Human FEN1 Immunohistochemistry Kit | IHC |
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