Anti-FGF23 Antibody Prodrug, Protease Activated (VS-1025-YC199)
CAT#: VS-1025-YC199
The Anti-FGF23 Antibody Prodrug, Protease Activated (VS-1025-YC199) is an antibody prodrug comprised of a recombinant human antibody targeting human FGF23, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to FGF23 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to FGF23 effectively. FGF23 is a hormone-like member of the FGF family that is produced by certain rare tumors (e.g., tumor-induced osteomalacia), leading to severe paraneoplastic syndromes. Its role is usually the direct result of the tumor producing the factor, causing systemic effects.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (AF22, HBEC3-KT)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118972-FGF23
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human FGF23
- Target
- FGF23
- Species Reactivity
- Human, Monkey
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).
- Alternative Names
- FGF23; ADHR; FGFN; HYPF; HPDR2; PHPTC
- Gene ID
- 8074
- UniProt ID
- Q9GZV9
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Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "FGF23"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2776z | Mouse Anti-FGF23 Recombinant Antibody (clone 33H1) | WB, ELISA, ICC, IHC | Mouse IgG |
| HPAB-0207-YC | Human Anti-FGF23 Recombinant Antibody (HPAB-0207-YC) | ELISA, FuncS | Human IgG |
| MOB-145YJL | Rat Anti-FGF23 Recombinant Antibody (clone CBF850) | WB, ELISA | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010ML | Anti-Human FGF23 Recombinant Antibody (TAB-010ML) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0207-YC-S(P) | Human Anti-FGF23 Recombinant Antibody; scFv Fragment (HPAB-0207-YC-S(P)) | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0207-YC-F(E) | Human Anti-FGF23 Recombinant Antibody; Fab Fragment (HPAB-0207-YC-F(E)) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-010ML | Afuco™ Anti-FGF23 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-010ML) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY107 | Human Anti-FGF23 scFv-Fc Chimera (VS-0425-FY107) | ELISA, FC, Neut | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2527 | Anti-FGF23 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2528 | Anti-Mouse FGF23 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC118 | Recombinant Anti-FGF23 Eliminating Antibody, pH-Sensitive (VS-0625-YC118) | Antigen-Sweeping In Vivo. | Human IgG1 kappa |
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