Human Anti-FGF23 scFv-Fc Chimera (VS-0425-FY107) (CAT#: VS-0425-FY107)

• Immunogen
• The immunogen is human FGF23.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human FGF23

• Species Reactivity
• Human

• Applications
• ELISA, Flow Cytometry, Neutralization

• Related Disease
• Hypophosphatemic Rickets, Autosomal Dominant and Tumoral Calcinosis, Hyperphosphatemic, Familial, 2

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Fibroblast Growth Factor 23; Phosphatonin; HYPF; Tumor-Derived Hypophosphatemia Inducing Factor; Tumor-Derived Hypophosphatemia-Inducing Factor; FGF-23

• Gene ID
• 8074

• UniProt ID
• Q9GZV9

• Long Name
• Fibroblast Growth Factor 23

• Sequence Similarities
• Belongs to the heparin-binding growth factors family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment.
  The processing is effected by proprotein convertases.
  O-glycosylated at Thr-171 and Thr-178 by GALNT3 and glycosylation of Thr-178 requires previous glycosylation at Thr171.
  Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated.
  Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23.
  Phosphorylation at Ser-180 mediated by FAM20C slows down glycosylation at Thr-178 notably.
  Glycosylation at Thr171 and Thr178
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 2 sites

• Protein Refseq
• NP_065689.1

• Function
• Regulator of phosphate homeostasis.
  Inhibits renal tubular phosphate transport by reducing SLC34A1 levels.
  Up-regulates EGR1 expression in the presence of KL.
  Acts directly on the parathyroid to decrease PTH secretion.
  Regulator of vitamin-D metabolism.
  Negatively regulates osteoblast differentiation and matrix mineralization.

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