Human Anti-FGF23 scFv-Fc Chimera (VS-0425-FY107)
CAT#: VS-0425-FY107
This scFv-Fc fusion protein targets FGF23 (Fibroblast growth factor 23), a hormone that regulates phosphate and vitamin D metabolism. By modulating FGF23 activity, it can influence mineral homeostasis and has potential applications in treating diseases related to phosphate metabolism disorders.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (AF22, HBEC3-KT)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118972-FGF23
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Specifications
- Immunogen
- The immunogen is human FGF23.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human FGF23
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry, Neutralization
- Related Disease
- Hypophosphatemic Rickets, Autosomal Dominant and Tumoral Calcinosis, Hyperphosphatemic, Familial, 2
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Fibroblast Growth Factor 23; Phosphatonin; HYPF; Tumor-Derived Hypophosphatemia Inducing Factor; Tumor-Derived Hypophosphatemia-Inducing Factor; FGF-23
- Gene ID
- 8074
- UniProt ID
- Q9GZV9
- Long Name
- Fibroblast Growth Factor 23
- Sequence Similarities
- Belongs to the heparin-binding growth factors family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment.
The processing is effected by proprotein convertases.
O-glycosylated at Thr-171 and Thr-178 by GALNT3 and glycosylation of Thr-178 requires previous glycosylation at Thr171.
Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated.
Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23.
Phosphorylation at Ser-180 mediated by FAM20C slows down glycosylation at Thr-178 notably.
Glycosylation at Thr171 and Thr178
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- NP_065689.1
- Function
- Regulator of phosphate homeostasis.
Inhibits renal tubular phosphate transport by reducing SLC34A1 levels.
Up-regulates EGR1 expression in the presence of KL.
Acts directly on the parathyroid to decrease PTH secretion.
Regulator of vitamin-D metabolism.
Negatively regulates osteoblast differentiation and matrix mineralization.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "FGF23"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2776z | Mouse Anti-FGF23 Recombinant Antibody (clone 33H1) | WB, ELISA, ICC, IHC | Mouse IgG |
| HPAB-0207-YC | Human Anti-FGF23 Recombinant Antibody (HPAB-0207-YC) | ELISA, FuncS | Human IgG |
| MOB-145YJL | Rat Anti-FGF23 Recombinant Antibody (clone CBF850) | WB, ELISA | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010ML | Anti-Human FGF23 Recombinant Antibody (TAB-010ML) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0207-YC-S(P) | Human Anti-FGF23 Recombinant Antibody; scFv Fragment (HPAB-0207-YC-S(P)) | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0207-YC-F(E) | Human Anti-FGF23 Recombinant Antibody; Fab Fragment (HPAB-0207-YC-F(E)) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-010ML | Afuco™ Anti-FGF23 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-010ML) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2527 | Anti-FGF23 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2528 | Anti-Mouse FGF23 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC118 | Recombinant Anti-FGF23 Eliminating Antibody, pH-Sensitive (VS-0625-YC118) | Antigen-Sweeping In Vivo. | Human IgG1 kappa |
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