Rabbit Anti-FKBP4 Recombinant Antibody (clone R08-4F8) (CAT#: VS3-FY2004)
The R08-4F8 recombinant monoclonal antibody detects human FKBP4. It cross-reacts with mouse, rat. It is suitable for use in a variety of assays, including WB, IHC-P. The binding specificity of the FKBP52 antibody was determined using western blot analysis of FKBP52 in Raw264.7 lysates and western blot analysis of FKBP52 in U2OS, C6 lysates.
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WB
Figure 1 Anti-FKBP4 Antibody (VS3-FY2004) in WB.
The FKBP52 expression in Raw264.7 lysates were detected using the anti-FKBP52 by western blot assay.
WB
Figure 2 Anti-FKBP4 Antibody (VS3-FY2004) in WB.
The FKBP52 expression in U2OS, C6 lysates were detected using the anti-FKBP52 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human FKBP52
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat FKBP4
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-4F8
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- MW
- The calculated weight of the target protein is approximately 52 kDa, while the observed molecular weight stands at 52 kDa.
- Related Disease
- Paralytic Lagophthalmos and Facial Nerve Disease
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- FK506 Binding Protein 4; FK506 Binding Protein 4, 59kDa; EC 5.2.1.8; Rotamase; FKBP51; FKBP52; FKBP59; HBI; Peptidyl-Prolyl Cis-Trans Isomerase FKBP4; T-Cell FK506-Binding Protein, 59kD; Peptidylprolyl Cis-Trans Isomerase; FK506-Binding Protein 4 (59kD); 51 KDa FK506-Binding Protein; 52 KDa FK506-Binding Protein
- Gene ID
- 2288
- UniProt ID
- Q02790
- Cellular Localization
- Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Mitochondrion, Nucleus
- Post Translation Modifications
- Phosphorylation by CK2 results in loss of HSP90 binding activity. (Q02790-FKBP4_HUMAN)
Ubiquitination at Lys28, Lys76, Lys83, Lys88, Lys222, Lys244, Lys250, Lys354, Lys378, and Lys409 (NX_Q02790 [NX_Q02790-1])
Modification sites at PhosphoSitePlus (Q02790)
Glycosylation from GlyGen (Q02790) 3 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_047284495.1; NP_002005.1
- Function
- May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0584CT | Recombinant Mouse anti-Human FKBP4 Monoclonal antibody (EML311) | ICC/IF, IHC-P, WB | |
| MRO-0594-CN | Rabbit Anti-FKBP4 Recombinant Antibody (clone JG96-30) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-WK337 | Rabbit Anti-FKBP4 Recombinant Antibody (clone JB95-39) | WB, ELISA | Rabbit IgG |
| VS3-FY2709 | Rabbit Anti-FKBP4 Recombinant Antibody (VS3-FY2709) | WB, ICC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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