Rabbit Anti-FOXC1 Recombinant Antibody (clone R06-3B5)
CAT#: VS3-FY1722
This anti-FOXC1 antibody detected positive in western blot analysis of FOXC1 in 3T3 lysates. The recombinant monoclonal antibody exhibits high affinity for human and mouse FOXC1. It is suitable for use in a variety of assays, including WB, IP.
Gene Expression
Tested Data
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/if_selected.jpg
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WB
Figure 1 Anti-FOXC1 Antibody (VS3-FY1722) in WB.
The FOXC1 expression in 3T3 lysates were detected using the anti-FOXC1 by western blot assay.
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Specifications
- Immunogen
- Recombinant human FOXC1 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse FOXC1
- Species Reactivity
- Human, Mouse
- Clone
- R06-3B5
- Applications
- Western Blot, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 57 kDa, while the observed molecular weight stands at 75 kDa.
- Related Disease
- Anterior Segment Dysgenesis 3 and Axenfeld-Rieger Syndrome, Type 3
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunoprecipitation: 1/20
Target
- Alternative Names
- Forkhead Box C1; Forkhead-Related Transcription Factor 3; Forkhead-Related Protein FKHL7; FREAC-3; FREAC3; FKHL7; Forkhead/Winged Helix-Like Transcription Factor 7; Forkhead, Drosophila, Homolog-Like 7; Forkhead-Related Activator 3; Forkhead Box C1 Protein
- Gene ID
- 2296
- UniProt ID
- Q12948
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated (PubMed:11782474, PubMed:19279310, PubMed:25786029).
Phosphorylated on Ser-272 in response to epidermal growth factor (EGF) in a ERK1/2 MAPK-dependent signaling pathway; phosphorylation contributes to its protein stability and transcriptional activity (PubMed:16492674).
- Protein Refseq
- NP_001444.2
- Function
- Acts as a transcriptional coactivator.
Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity).
Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells.
Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "FOXC1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-994-sdAb | Recombinant Anti-Human FOXC1 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-003CQ | Rabbit Anti-Human FOXC1 Polyclonal Antibody | WB, IF, ICC, ChIP | Rabbit IgG |
| VS13-YC415 | Rabbit Anti-FOXC1 Recombinant Antibody (VS13-YC415) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2621 | Anti-FOXC1 Immunohistochemistry Kit | IHC |
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