Rabbit Anti-FOXC1 Recombinant Antibody (VS13-YC415)
CAT#: VS13-YC415
The Rabbit Anti-FOXC1 Recombinant Antibody is specific for human FOXC1. FOXC1, another forkhead transcription factor, influences embryonic and ocular development, mutations leading to glaucoma through regulatory pathway impacts in gene expression. The anti-FOXC1 antibody can be used for Immunohistochemistry (1/100-1/200).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/415_H8_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/416_H8_1_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AN3-CA, HEK93, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000054598-FOXC1
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Specifications
- Immunogen
- Recombinant human FOXC1.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human FOXC1
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
- Related Disease
- Anterior Segment Dysgenesis and Axenfeld-Rieger Syndrome, Type 3
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- Forkhead Box C1; Forkhead-Related Transcription Factor 3; Forkhead-Related Protein FKHL7; FREAC-3; FREAC3; FKHL7; Forkhead/Winged Helix-Like Transcription Factor 7; Forkhead, Drosophila, Homolog-Like 7; Forkhead-Related Activator 3; Forkhead Box C1 Protein;
- Gene ID
- 2296
- UniProt ID
- Q12948
- Long Name
- Forkhead Box C1
- Cellular Localization
- Nucleus
- Protein Refseq
- NP_001444.2
- Function
- Acts as a transcriptional coactivator.
Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity).
Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells.
Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "FOXC1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-994-sdAb | Recombinant Anti-Human FOXC1 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-003CQ | Rabbit Anti-Human FOXC1 Polyclonal Antibody | WB, IF, ICC, ChIP | Rabbit IgG |
| VS3-FY1722 | Rabbit Anti-FOXC1 Recombinant Antibody (clone R06-3B5) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2621 | Anti-FOXC1 Immunohistochemistry Kit | IHC |
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