Rabbit Anti-FOXC1 Recombinant Antibody (VS13-YC415) (CAT#: VS13-YC415)
The Rabbit Anti-FOXC1 Recombinant Antibody is specific for human FOXC1. FOXC1, another forkhead transcription factor, influences embryonic and ocular development, mutations leading to glaucoma through regulatory pathway impacts in gene expression. The anti-FOXC1 antibody can be used for Immunohistochemistry (1/100-1/200).
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Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/if_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/415_H8_1_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/415_H8_1_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/416_H8_1_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40670/416_H8_1_red_green.jpg
Figure 4 RNA cell line category: Cell line enhanced (AN3-CA, HEK93, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000054598-FOXC1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000054598-FOXC1
Specifications
- Immunogen
- Recombinant human FOXC1.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human FOXC1
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
- Related Disease
- Anterior Segment Dysgenesis and Axenfeld-Rieger Syndrome, Type 3
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- Forkhead Box C1; Forkhead-Related Transcription Factor 3; Forkhead-Related Protein FKHL7; FREAC-3; FREAC3; FKHL7; Forkhead/Winged Helix-Like Transcription Factor 7; Forkhead, Drosophila, Homolog-Like 7; Forkhead-Related Activator 3; Forkhead Box C1 Protein;
- Gene ID
- 2296
- UniProt ID
- Q12948
- Long Name
- Forkhead Box C1
- Cellular Localization
- Nucleus
- Protein Refseq
- NP_001444.2
- Function
- Acts as a transcriptional coactivator.
Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity).
Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells.
Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single Domain Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-994-sdAb | Recombinant Anti-Human FOXC1 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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